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Difference between revisions of "Prostate gland"
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==Cancer== | ==Cancer== | ||
===Criteria as a list=== | ===Criteria as a list=== | ||
Major criteria:<ref name=pmid17213347>{{cite journal |author=Humphrey PA |title=Diagnosis of adenocarcinoma in prostate needle biopsy tissue |journal=J. Clin. Pathol. |volume=60 |issue=1 |pages=35–42 |year=2007 |month=January |pmid=17213347 |pmc=1860598 |doi=10.1136/jcp.2005.036442 |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860598/?tool=pubmed}}</ref> | Major criteria (the ABCs of prostate pathology):<ref name=pmid17213347>{{cite journal |author=Humphrey PA |title=Diagnosis of adenocarcinoma in prostate needle biopsy tissue |journal=J. Clin. Pathol. |volume=60 |issue=1 |pages=35–42 |year=2007 |month=January |pmid=17213347 |pmc=1860598 |doi=10.1136/jcp.2005.036442 |url=http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1860598/?tool=pubmed}}</ref> | ||
#" | #Architecture: "infiltrative growth" pattern. | ||
# | #Basal cells lacking | ||
#Nuclear enlargement. | #Cytological abnormalities: | ||
#Nucleoli. | #*Nuclear enlargement. | ||
#*Nucleoli. | |||
Minor criteria:<ref name=pmid17213347/> | Minor criteria:<ref name=pmid17213347/> | ||
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**The prostate, at the apex, may have some skeletal muscle -- it is hard to define the extent... ergo no EPE at apex. (????) | **The prostate, at the apex, may have some skeletal muscle -- it is hard to define the extent... ergo no EPE at apex. (????) | ||
===Elements of a prostate biopsy report with cancer=== | ===Reporting prostate cancer=== | ||
====Elements of a prostate biopsy report with cancer==== | |||
Important elements:<ref name=pmid17213347/> | |||
#Type of cancer, e.g. "prostatic adenocarcinoma, acinar type". | #Type of cancer, e.g. "prostatic adenocarcinoma, acinar type". | ||
#Gleason score including primary and secondary pattern, e.g. "Gleason score 3+4=7". | #Gleason score including primary and secondary pattern, e.g. "Gleason score 3+4=7". | ||
#Number of cores involved, e.g. "2/3 cores involved". | #Number of cores and number involved, e.g. "2/3 cores involved by cancer". | ||
#Percent area involved, i.e. how much of the core is cancer, e.g. "75% of specimen is tumour". | #Percent area involved, i.e. how much of the core is cancer, e.g. "75% of specimen is tumour". | ||
#Percent area involved that is Gleason pattern 4 or 5, e.g. "25 of the tumour is Gleason pattern 4 or 5". | #Percent area involved that is Gleason pattern 4 or 5, e.g. "25% of the tumour is Gleason pattern 4 or 5". | ||
#Presence of perineural invasion. | #Presence of perineural invasion. | ||
#Presence of extension into fat (extraprostatic extension). | #Presence of extension into fat (extraprostatic extension). | ||
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Notes: | Notes: | ||
*"Percent area involved" may seem like an odd thing to request 'cause it is sampling dependent, i.e. if the radiologist sticks the biopsy needle deeper into the lesion more of the core is positive, but urologists think it is important -- more important than perineural invasion.<ref>{{cite journal |author=Rubin MA, Bismar TA, Curtis S, Montie JE |title=Prostate needle biopsy reporting: how are the surgical members of the Society of Urologic Oncology using pathology reports to guide treatment of prostate cancer patients? |journal=Am. J. Surg. Pathol. |volume=28 |issue=7 |pages=946–52 |year=2004 |month=July |pmid=15223967 |doi= |url=}}</ref> | *"Percent area involved" may seem like an odd thing to request 'cause it is sampling dependent, i.e. if the radiologist sticks the biopsy needle deeper into the lesion more of the core is positive, but urologists think it is important -- more important than perineural invasion.<ref>{{cite journal |author=Rubin MA, Bismar TA, Curtis S, Montie JE |title=Prostate needle biopsy reporting: how are the surgical members of the Society of Urologic Oncology using pathology reports to guide treatment of prostate cancer patients? |journal=Am. J. Surg. Pathol. |volume=28 |issue=7 |pages=946–52 |year=2004 |month=July |pmid=15223967 |doi= |url=}}</ref> | ||
====Prostatectomy specimens==== | |||
See: [http://www.cap.org/apps/cap.portal?_nfpb=true&cntvwrPtlt_actionOverride=/portlets/contentViewer/show&_windowLabel=cntvwrPtlt&cntvwrPtlt{actionForm.contentReference}=committees/cancer/cancer_protocols/protocols_index.html&_pageLabel=cntvwr CAP checklist]. | |||
==HGPIN (high grade prostatic intraepithelial neoplasia)== | ==HGPIN (high grade prostatic intraepithelial neoplasia)== | ||
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*HGPIN: AMACR+, p63+, HMWCK+. | *HGPIN: AMACR+, p63+, HMWCK+. | ||
*Normal: AMACR-, p63+, HMWCK+. | *Normal: AMACR-, p63+, HMWCK+. | ||
==Atrophy== | ==Atrophy== | ||