14
edits
Difference between revisions of "Prostate gland"
Jump to navigation
Jump to search
m
added a word for clarity
(→Specific conditions: subdivide, add 'adenosis of the prostate') |
Alessandro (talk | contribs) m (added a word for clarity) |
||
| (4 intermediate revisions by one other user not shown) | |||
| Line 19: | Line 19: | ||
**Second cell layer may be difficult to see (like in breast). | **Second cell layer may be difficult to see (like in breast). | ||
*Epithelium in glands is "folded" or "tufted". | *Epithelium in glands is "folded" or "tufted". | ||
**Very important - helps | **Very important - helps to differentiate from Gleason pattern 3. | ||
*Luminal epithelium often clear cytoplasm. | *Luminal epithelium often clear cytoplasm. | ||
*Single nucleus. | *Single nucleus. | ||
| Line 36: | Line 36: | ||
Notes: | Notes: | ||
*Tufted epithelium is a strong indicator of benignancy; however two uncommon prostate cancer typically have tufted epithelium: | *Tufted epithelium is a strong indicator of benignancy; however two uncommon prostate cancer variants typically have tufted epithelium: | ||
**[[Pseudohyperplastic adenocarcinoma]]. | **[[Pseudohyperplastic adenocarcinoma]]. | ||
**[[Foamy gland carcinoma]]. | **[[Foamy gland carcinoma]]. | ||
| Line 49: | Line 49: | ||
Normal prostate: | Normal prostate: | ||
*[[AMACR]] -ve (mark epithelial cells). | *[[AMACR]] -ve (mark epithelial cells). | ||
*CK5/6 +ve,<ref name=pmid19605815>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Bartczak-McKay | first2 = J. | last3 = Yilmaz | first3 = A. | title = Usefulness of cytokeratin 5/6 and AMACR applied as double sequential immunostains for diagnostic assessment of problematic prostate specimens. | journal = Am J Clin Pathol | volume = 132 | issue = 2 | pages = 211-20; quiz 307 | month = Aug | year = 2009 | doi = 10.1309/AJCPGFJP83IXZEUR | PMID = 19605815 }}</ref> p63 +ve, HMWCK +ve (mark basal cells). | *[[CK5/6]] +ve,<ref name=pmid19605815>{{Cite journal | last1 = Trpkov | first1 = K. | last2 = Bartczak-McKay | first2 = J. | last3 = Yilmaz | first3 = A. | title = Usefulness of cytokeratin 5/6 and AMACR applied as double sequential immunostains for diagnostic assessment of problematic prostate specimens. | journal = Am J Clin Pathol | volume = 132 | issue = 2 | pages = 211-20; quiz 307 | month = Aug | year = 2009 | doi = 10.1309/AJCPGFJP83IXZEUR | PMID = 19605815 }}</ref> p63 +ve, HMWCK +ve (mark basal cells). | ||
*PSA (prostate-specific antigen) +ve, PSAP (prostatic-specific acid phosphatase) +ve. | *PSA ([[prostate-specific antigen]]) +ve, PSAP ([[prostatic-specific acid phosphatase]]) +ve. | ||
==Sign out== | ==Sign out== | ||
| Line 88: | Line 88: | ||
==Common diagnoses== | ==Common diagnoses== | ||
*Benign. | *Benign. | ||
**[[ | **[[Atrophy of the prostate|Atrophy]] - may resemble adenocarcinoma - typically not reported. | ||
**Adenosis - may resemble adenocarcinoma - typically not reported. | **[[Adenosis of the prostate|Adenosis]] - may resemble adenocarcinoma - typically not reported. | ||
*[[Prostate adenocarcinoma]]. | *[[Prostate adenocarcinoma]]. | ||
*[[HGPIN]] (high-grade prostatic intraepithelial neoplasia) - prostate adenocarcinoma precursor lesion. | *[[HGPIN]] (high-grade prostatic intraepithelial neoplasia) - prostate adenocarcinoma precursor lesion. | ||
*[[ASAP]] (atypical small acinar proliferation) - used if you have a few abnormal appearing glands... but can't decide between prostate adenocarcinoma & benign. | *[[ASAP]] (atypical small acinar proliferation) - used if you have a few abnormal appearing glands... but can't decide between prostate adenocarcinoma & benign. | ||