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Difference between revisions of "Prostate gland"
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→High-grade prostatic intraepithelial neoplasia
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features:<ref name=Ref_Amin3-56>{{Ref Amin|3-56}}</ref><ref name=pmid2002502>{{Cite journal | last1 = Chin | first1 = AI. | last2 = Dave | first2 = DS. | last3 = Rajfer | first3 = J. | title = Is repeat biopsy for isolated high-grade prostatic intraepithelial neoplasia necessary? | journal = Rev Urol | volume = 9 | issue = 3 | pages = 124-31 | month = | year = 2007 | doi = | PMID = 17934569 | PMC = 2002502 }}</ref> | ||
* | *Medium to large glands with architectural changes - see ''HGPIN architecture'' below. | ||
**Described as "epithelial hyperplasia". | |||
*Diagnosed on basis of nuclear changes. | *Diagnosed on basis of nuclear changes. | ||
**Hyperchromatic nuclei - '''key (low power) feature'''. | **Hyperchromatic nuclei - '''key (low power) feature'''. | ||
**Nucleoli present - '''key (high power) feature'''. | **Nucleoli present - '''key (high power) feature'''. | ||
**Often increased | **Often increased NC ratio. | ||
**Nuclear enlargement. | **Nuclear enlargement. | ||
Notes: | Notes: | ||
*Nucleoli should be visible with the 20x objective. | *Nucleoli should be visible with the 20x objective. | ||
**If one uses the 40x objective... one over calls. | **If one uses the 40x objective... one over calls. | ||
**Some pathologists require nucleoli to be present in >= 10% of cells in a gland to call it HGPIN. | |||
*May need IHC for cancer versus HGPIN. | *May need IHC for cancer versus HGPIN. | ||