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Difference between revisions of "Prostate cancer grading"
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Prostate cancer grading (view source)
Revision as of 16:37, 10 October 2018
, 16:37, 10 October 2018→When to use/not to use
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***A biopsy with 98% Gleason pattern 4 and 2% Gleason pattern 3 would be graded as 8/10 (4+4). | ***A biopsy with 98% Gleason pattern 4 and 2% Gleason pattern 3 would be graded as 8/10 (4+4). | ||
*Reported as on prostatectomies as: (primary pattern) + (secondary pattern) = sum, (tertiary pattern) | *Reported as on prostatectomies as: (primary pattern) + (secondary pattern) = sum, (tertiary pattern) | ||
====When to use/not to use==== | |||
The ''College of American Pathologist'' synoptic (''Cancer Protocol Template'') says:<ref>Srigley JR ''et al.'', "Protocol for the Examination of Specimens From Patients With Carcinoma of the Prostate Gland", College of American Pathologists, Version: 4.0.3.0. (June 2017), Accessed on: 10 October 2018.</ref> | |||
*Grade all prostate specimens with adenocarcinoma except those with prior treatment changes (e.g. radiation therapy changes or anti-androgen changes). | |||
====Tertiary Gleason pattern==== | ====Tertiary Gleason pattern==== | ||
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The change in the order of the Gleason score components (3+4 on prostatectomy | The change in the order of the Gleason score components (3+4 on prostatectomy | ||
versus 4+3 on core biopsy) may be explained by sampling. | versus 4+3 on core biopsy) may be explained by sampling. | ||
</pre> | |||
====Separate nodule upgrades prostatectomy==== | |||
<pre> | |||
A tumour nodule in the left mid portion of the gland (1.2 cm) is predominantly 4+3; the Gleason score for the case is assigned on the basis of the tumour nodule as Gleason score 7/10 (4+3). | |||
Overall, Gleason pattern 3 represents 65% of the cancer in the prostate, and Gleason pattern 4 represents 35% of the cancer in the prostate. | |||
</pre> | </pre> | ||
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*[[AKA]] ''prognostic Gleason grade groupings''. | *[[AKA]] ''prognostic Gleason grade groupings''. | ||
*[[AKA]] ''a contemporary prostate cancer grading system'', abbreviated ''CPCGS''. | *[[AKA]] ''a contemporary prostate cancer grading system'', abbreviated ''CPCGS''. | ||
*[[AKA]] ''Gleason group''.<ref>URL: [http://www.cancer.net/cancer-types/prostate-cancer/stages-and-grades http://www.cancer.net/cancer-types/prostate-cancer/stages-and-grades]. Accessed on: May 1, 2017.</ref> | |||
This system has been proposed. Currently, it is not widely used. The name of the system is ''not'' completely settled. | |||
This system has been proposed. Currently, it is not widely used. The name of the system is ''not'' completely settled. | This system has been proposed. Currently, it is not widely used. The name of the system is ''not'' completely settled. | ||
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====Reporting examples==== | ====Reporting examples==== | ||
Within a synoptic report: | |||
<pre> | |||
Grade group: Grade Group 3, Gleason score 4+3=7. | |||
</pre> | |||
As a comment: | As a comment: | ||
<pre> | <pre> | ||
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</pre> | </pre> | ||
=====Alternates===== | |||
<pre> | |||
The World Health Organization (WHO) prostate cancer grade is: 3 out of 5. Gleason pattern 3 represents 30% of the tumour, and Gleason pattern 4 represents 70% of the tumour. | |||
</pre> | |||
<pre> | <pre> | ||
Gleason pattern 3 represents 30% of the tumour, and Gleason pattern 4 represents 70% of the tumour. | |||
The World Health Organization (WHO) endorsed prostate cancer grade grouping is: 3 out of 5. | |||
</pre> | </pre> | ||
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*[[Prostate cancer staging]]. | *[[Prostate cancer staging]]. | ||
*[[Cancer staging systems]]. | *[[Cancer staging systems]]. | ||
*[[Cribriform pattern within invasive prostate carcinoma]]. | |||
*[[Apparent diffusion coefficient]]. | |||
==References== | ==References== | ||