48,460
edits
Difference between revisions of "Prostate cancer grading"
Jump to navigation
Jump to search
→Overview
| Line 18: | Line 18: | ||
*Reported as on prostatectomies as: (primary pattern) + (secondary pattern) = sum, (tertiary pattern) | *Reported as on prostatectomies as: (primary pattern) + (secondary pattern) = sum, (tertiary pattern) | ||
====Tertiary Gleason pattern==== | |||
**The Foundation series GU book (1st Ed.) defines ''Tertiary Gleason pattern'' as:<ref name=Ref_GUP72>{{Ref GUP|72}}</ref> a pattern that is seen in less than 5% of the tumour | *Unfortunately there is no consensus definition for ''tertiary Gleason pattern''.<ref name=Koloffa>{{Cite journal | last1 = Koloffa | first1 = ZB | last2 = Hamstrab | first2 = DA | last3 = Weia | first3 = JT | last4 = Montgomerya | first4 = JS ''et al''| title = Impact of tertiary Gleason pattern 5 on prostate cancer aggressiveness: Lessons from a contemporary single institution radical prostatectomy series | journal = Asian Journal of Urology | volume = 2 | issue = 1| pages = 53–58 | month = | year = 2015 | doi = 10.1016/j.ajur.2015.04.007 | PMID = | PMC = | url = http://www.sciencedirect.com/science/article/pii/S2214388215000302 }}</ref> | ||
**The Foundation series GU book (1st Ed.) defines ''Tertiary Gleason pattern'' as:<ref name=Ref_GUP72>{{Ref GUP|72}}</ref> a pattern that is seen in less than 5% of the tumour that is of a higher grade than the two dominant patterns. | |||
**Koloffa ''et al''<ref name=Koloffa/> notes that some define it as: the third most prevalent pattern and most require that it is a higher grade than the two dominant patterns. | **Koloffa ''et al''<ref name=Koloffa/> notes that some define it as: the third most prevalent pattern and most require that it is a higher grade than the two dominant patterns. | ||
***Parsed with the all the subtleties - working definition could be: The third most prevalent pattern ''and'' a higher grade than the two dominant patterns ''or'' a pattern that is seen in less than 5% of the tumour and of higher grade than one pattern that comprises >95% of the tumour. | ***Parsed with the all the subtleties - working definition could be: The third most prevalent pattern ''and'' a higher grade than the two dominant patterns ''or'' a pattern that is seen in less than 5% of the tumour and of higher grade than one pattern that comprises >95% of the tumour. | ||