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Difference between revisions of "Prostate cancer grading"
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This article deals with '''prostate cancer grading'''. | This article deals with '''prostate cancer grading'''. | ||
It covers the '''Gleason | It covers the '''Gleason system''' and the proposed '''Prostate cancer grading system endorsed by the WHO'''. | ||
''Prostate cancer'' is dealt with in the ''[[prostate cancer]]'' article. | ''Prostate cancer'' is dealt with in the ''[[prostate cancer]]'' article. | ||
| Line 206: | Line 206: | ||
</pre> | </pre> | ||
==Prostate cancer grading endorsed by the WHO== | ==Prostate cancer grading system endorsed by the WHO== | ||
*[[AKA]] ''WHO prostate grading system''. | *[[AKA]] ''WHO prostate grading system''. | ||
*[[AKA]] ''grade groupings''. | *[[AKA]] ''grade groupings''. | ||
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*[[AKA]] ''a contemporary prostate cancer grading system'', abbreviated ''CPCGS''. | *[[AKA]] ''a contemporary prostate cancer grading system'', abbreviated ''CPCGS''. | ||
===Gleason score & | ===Gleason score & WHO system=== | ||
Proposed new system and old (modified) Gleason score:<ref name=jhu2014>URL: [http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php]. Accessed on: 28 March 2015.</ref><ref name=pmid26166626>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Zelefsky | first2 = MJ. | last3 = Sjoberg | first3 = DD. | last4 = Nelson | first4 = JB. | last5 = Egevad | first5 = L. | last6 = Magi-Galluzzi | first6 = C. | last7 = Vickers | first7 = AJ. | last8 = Parwani | first8 = AV. | last9 = Reuter | first9 = VE. | title = A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score. | journal = Eur Urol | volume = | issue = | pages = | month = Jul | year = 2015 | doi = 10.1016/j.eururo.2015.06.046 | PMID = 26166626 }}</ref> | Proposed new system (endorsed by the WHO) and old (modified) Gleason score:<ref name=jhu2014>URL: [http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php http://urology.jhu.edu/newsletter/2014/prostate_cancer_2014_19.php]. Accessed on: 28 March 2015.</ref><ref name=pmid26166626>{{Cite journal | last1 = Epstein | first1 = JI. | last2 = Zelefsky | first2 = MJ. | last3 = Sjoberg | first3 = DD. | last4 = Nelson | first4 = JB. | last5 = Egevad | first5 = L. | last6 = Magi-Galluzzi | first6 = C. | last7 = Vickers | first7 = AJ. | last8 = Parwani | first8 = AV. | last9 = Reuter | first9 = VE. | title = A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score. | journal = Eur Urol | volume = | issue = | pages = | month = Jul | year = 2015 | doi = 10.1016/j.eururo.2015.06.046 | PMID = 26166626 }}</ref> | ||
{| class="wikitable sortable" style="text-align:center;margin-left:auto;margin-right:auto" | {| class="wikitable sortable" style="text-align:center;margin-left:auto;margin-right:auto" | ||
! | ! WHO grade | ||
! Gleason score | ! Gleason score | ||
|- | |- | ||
| Line 239: | Line 239: | ||
===Prognostication=== | ===Prognostication=== | ||
Recurrence free progression stratified by | Recurrence free progression stratified by WHO:<ref name=pmid26166626/> | ||
{| class="wikitable sortable" style="text-align:center;margin-left:auto;margin-right:auto" | {| class="wikitable sortable" style="text-align:center;margin-left:auto;margin-right:auto" | ||
! Prognostic group ( | ! Prognostic group (WHO) | ||
! Hazard ratio<br>compared to Group I | ! Hazard ratio<br>compared to Group I | ||
|- | |- | ||