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Difference between revisions of "Prostate cancer"
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→High power features
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*Nuclei. | *Nuclei. | ||
**Hyperchromatic nuclei (like in HGPIN). | **Hyperchromatic nuclei (like in HGPIN). | ||
**Nuclear enlargement. | **Nuclear enlargement, mild (10%?). | ||
***Difficult to appreciate (if cancer isn't side-by-side with normal prostate). | ***Difficult to appreciate (if cancer isn't side-by-side with normal prostate). | ||
***Difficult/impossible to see at low power. | ***Difficult/impossible to see at low power. | ||
*Nucleoli visible on high power (200x or | *Nucleoli visible on high power (200x or 100x magnification). | ||
**May be difficult to see - especially if light intensity is low. | **May be difficult to see - especially if light intensity is low. | ||
***One should not use 400x to look for nucleoli (it is a waste of time + you risk | ***One should not use 400x to look for nucleoli (it is a waste of time + you risk over-calling something benign). | ||
**If I see three good nucleoli in a gland and the architecture is abnormal, I'm usually confident it is cancer. | **If I see three good nucleoli in a gland and the architecture is abnormal, I'm usually confident it is badness ([[ASAP]] or [[prostate cancer|cancer]]). | ||
*Loss of basal cells - diagnostic feature. | *Loss of basal cells - diagnostic feature. | ||
**Like in [[breast pathology]] (where one looks for loss of myoepithelial cells) - this may be difficult to see. | **Like in [[breast pathology]] (where one looks for loss of myoepithelial cells) - this may be difficult to see. | ||
Notes: | Notes: | ||
*Mitoses are not a common feature - | *Mitoses are not a common feature. | ||
**If you find them the lesion is probably high-grade. | |||
**Generally, it isn't worth looking for them. | |||
===Mimics=== | ===Mimics=== | ||