Difference between revisions of "Poorly differentiated carcinoma of the lung"

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'''Poorly differentiated carcinoma of the lung''', also '''poorly differentiated lung carcinoma''', is an unclassified [[lung tumour]] with features of [[small cell carcinoma of the lung|small cell carcinoma]] and [[non-small cell lung carcinoma]]. 
#redirect [[Non-small cell lung carcinoma]]
 
Categorically, it is grouped with [[non-small cell lung cancer]].
 
==General==
*Should be used when the DDx is ''small cell carcinoma'' versus ''non-small cell carcinoma''.
*''Poorly differentiated carcinoma'' leaves the surgical options on the table.
 
Clinical:
*Radiologic findings should not be suggestive of a metastasis.
 
==Microscopic==
Features:
*Small cell carcinoma/basaloid squamous cell carcinoma-like tumour.
 
DDx:
*[[Lung metastasis]] - imaging suggestive of a metastasis or a history of malignancy.
*[[Small cell carcinoma of the lung]].
*[[Squamous cell carcinoma of the lung]].
 
==IHC==
*Lack of staining with [[neuroendocrine markers]] (chromogranin A -ve, synaptophysin -ve, CD56 -ve).
*Keratins +ve.
 
==Sign out==
<pre>
Lung, Left Lower Lobe, Core Biopsy:
- POORLY DIFFERENTIATED CARCINOMA, see comment.
 
COMMENT:
The tumour stains as follows:
POSITIVE: EMA, AE1/AE3.
NEGATIVE: TTF-1, chromogranin A, synaptophysin, CD56, CD45, CK5/6, p63.
 
The morphology would be compatible with small cell carcinoma or basaloid
squamous cell carcinoma. 
 
The neuroendocrine markers (chromogranin A, synaptophysin, CD56) and the squamoid
markers available (p63, CK5/6) are negative; thus, the tumour is not further classified.
</pre>
 
==See also==
*[[Lung tumours]].
*[[Non-small cell lung carcinoma]].
 
[[Category:Lung tumours]]

Latest revision as of 04:28, 18 November 2015

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