Difference between revisions of "Poorly differentiated carcinoma of the lung"

Latest revision as of 04:28, 18 November 2015

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-'''Poorly differentiated carcinoma of the lung''', also '''poorly differentiated lung carcinoma''', is an unclassified [[lung tumour]] with features of [[small cell carcinoma of the lung|small cell carcinoma]] and [[non-small cell carcinoma]].
+#redirect [[Non-small cell lung carcinoma]]
-Categorically, it is group of [[non-small cell lung cancer]].
-==General==
-*Should be used when the DDx is ''small cell carcinoma'' versus ''non-small cell carcinoma''.
-*''Poorly differentiated carcinoma'' leaves the surgical options on the table.
-==Microscopic==
-Features:
-*Small cell carcinoma/basaloid squamous cell carcinoma-like tumour.
-DDx:
-*[[Metastatic lung cancer]].
-*[[Small cell carcinoma of the lung]].
-*[[Squamous cell carcinoma of the lung]].
-==IHC==
-*Lack of staining with [[neuroendocrine markers]] (chromogranin A -ve, synaptophysin -ve, CD56 -ve).
-*Keratins +ve.
-==Sign out==
-<pre>
-Lung, Left Lower Lobe, Core Biopsy:
-- POORLY DIFFERENTIATED CARCINOMA, see comment.
-COMMENT:
-The tumour stains as follows:
-POSITIVE: EMA, AE1/AE3.
-NEGATIVE: TTF-1, chromogranin A, synaptophysin, CD56, CD45.
-The morphology would be compatible with small cell carcinoma or basaloid
-squamous cell carcinoma.
-The neuroendocrine markers (chromogranin A, synaptophysin, CD56) and the squamoid
-markers available (p63, CK5/6) are negative; thus, the tumour is not further classified.
-</pre>
-==See also==
-*[[Lung tumours]].
-[[Category:Lung tumours]]