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'''Polymorphous_low-grade_adenocarcinoma''', abbreviated '''PLGA''', is a rare malignant [[salivary gland]] tumour. | |||
==General== | |||
*Almost exclusively in the oral cavity. | |||
**Classically found in the palate -- 60% of PLGAs in palate. | |||
*Tumour of the minor salivary glands. | |||
*Always a low-grade tumour - by definition. | |||
*Female:male ~= 2:1. | |||
*Older people ~50-70 years old. | |||
==Microscopic== | |||
Features:<ref name=Ref_WMSP74>{{Ref WMSP|74}} <!-- Mike S. --></ref> | |||
*Architecture: often small nests, may be targetoid. | |||
**Classically has whorling with '''eye-of-storm''' & '''single file'''. | |||
*Cytologically monotonous (uniform) with variable architecture - '''key feature'''. | |||
**Nucleus: ovoid & small, small nucleoli, powdery chromatin. | |||
***'''[[Papillary thyroid carcinoma]]-like appearance'''. | |||
**Cytoplasm: eosinophilic. | |||
*Indistinct cell borders. | |||
DDx: | |||
*[[Adenoid cystic carcinoma]]. | |||
*[[Pleomorphic adenoma]]. | |||
*Cribriform adenocarcinoma of the minor salivary gland.<ref name=pmid21716087>{{Cite journal | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }} | |||
</ref> | |||
===Images=== | |||
<gallery> | |||
Image:Polymorphous_low-grade_adenocarcinoma_-_very_low_mag.jpg | PLGA - very low mag. (WC/Nephron) | |||
Image:Polymorphous_low-grade_adenocarcinoma_high_mag.jpg | PLGA - high mag. (WC/Nephron) | |||
</gallery> | |||
==IHC== | |||
*S100 +ve, CK +ve, vimentin +ve. | |||
*GFAP +ve/-ve. | |||
*BCL2 +ve/-ve. | |||
*Generally negative for myoepithelial markers (calponin, actin) - '''useful if negative'''. | |||
==See also== | |||
*[[Salivary glands]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Salivary gland]] | |||