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Difference between revisions of "Polymorphous adenocarcinoma"
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Polymorphous adenocarcinoma (view source)
Revision as of 18:27, 18 March 2015
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| Micro = low-grade cytology - nuclei ovoid & small, small nucleoli, powdery chromatin ([[papillary thyroid carcinoma]]-like appearance); eosinophilic cytoplasm; variable architecture - often small nests, classically has whorling ("eye-of-storm") pattern and single file pattern | | Micro = low-grade cytology - nuclei ovoid & small, small nucleoli, powdery chromatin ([[papillary thyroid carcinoma]]-like appearance); eosinophilic cytoplasm; variable architecture - often small nests, classically has whorling ("eye-of-storm") pattern and single file pattern | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[adenoid cystic carcinoma]], [[pleomorphic adenoma]], cribriform adenocarcinoma of the minor salivary gland | | LMDDx = [[adenoid cystic carcinoma]], [[pleomorphic adenoma]], [[cribriform adenocarcinoma of the minor salivary gland]] | ||
| Stains = | | Stains = | ||
| IHC = | | IHC = S-100 +ve, CK7 +ve, vimentin +ve | ||
| EM = | | EM = | ||
| Molecular = | | Molecular = | ||
| Line 20: | Line 20: | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
| Prevalence = | | Prevalence = uncommon (varies by study) | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = | | Prognosis = good | ||
| Other = | | Other = | ||
| ClinDDx = | | ClinDDx = | ||
| Line 31: | Line 31: | ||
==General== | ==General== | ||
*Female:male ~= 2:1. | *Female:male ~= 2:1. | ||
*Older people ~50-70 years old. | *Older people ~50-70 years old. | ||
*Large variably in the prevalence reported - suggests a lacking of reproducibility in the [[diagnosis]].<ref name=pmid23320410/> | |||
*Slow growing - metastases rare - prognosis good.<ref name=pmid18327037>{{Cite journal | last1 = Paleri | first1 = V. | last2 = Robinson | first2 = M. | last3 = Bradley | first3 = P. | title = Polymorphous low-grade adenocarcinoma of the head and neck. | journal = Curr Opin Otolaryngol Head Neck Surg | volume = 16 | issue = 2 | pages = 163-9 | month = Apr | year = 2008 | doi = 10.1097/MOO.0b013e3282f70441 | PMID = 18327037 }}</ref><ref name=pmid23618791>{{Cite journal | last1 = Fife | first1 = TA. | last2 = Smith | first2 = B. | last3 = Sullivan | first3 = CA. | last4 = Browne | first4 = JD. | last5 = Waltonen | first5 = JD. | title = Polymorphous low-grade adenocarcinoma: a 17 patient case series. | journal = Am J Otolaryngol | volume = 34 | issue = 5 | pages = 445-8 | month = | year = | doi = 10.1016/j.amjoto.2013.03.012 | PMID = 23618791 }}</ref> | |||
==Gross== | |||
*Tumour of the minor [[salivary gland]]s.<ref name=pmid24021444>{{Cite journal | last1 = Andreu-Barasoain | first1 = M. | last2 = Vicente-Martín | first2 = FJ. | last3 = Gómez de la Fuente | first3 = E. | last4 = Salamanca-Santamaría | first4 = J. | last5 = Pampín-Franco | first5 = A. | last6 = López-Estebaranz | first6 = JL. | title = Polymorphous low-grade adenocarcinoma in the upper lip: a well-described but infrequently recognized tumor. | journal = Dermatol Online J | volume = 19 | issue = 8 | pages = 19265 | month = | year = 2013 | doi = | PMID = 24021444 }}</ref> | |||
*Almost exclusively in the [[oral cavity]] - usually palate.<ref name=pmid18327037/> | |||
==Microscopic== | ==Microscopic== | ||
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**Cytoplasm: eosinophilic. | **Cytoplasm: eosinophilic. | ||
*Indistinct cell borders. | *Indistinct cell borders. | ||
Note: | |||
*'''Always''' a low-grade tumour - by definition. | |||
DDx: | DDx: | ||
*[[Adenoid cystic carcinoma]]. | *[[Adenoid cystic carcinoma]]. | ||
*[[Pleomorphic adenoma]]. | *[[Pleomorphic adenoma]]. | ||
*Cribriform adenocarcinoma of the minor salivary gland.<ref name=pmid21716087>{{Cite journal | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }} | *[[Cribriform adenocarcinoma of the minor salivary gland]].<ref name=pmid21716087>{{Cite journal | last1 = Skalova | first1 = A. | last2 = Sima | first2 = R. | last3 = Kaspirkova-Nemcova | first3 = J. | last4 = Simpson | first4 = RH. | last5 = Elmberger | first5 = G. | last6 = Leivo | first6 = I. | last7 = Di Palma | first7 = S. | last8 = Jirasek | first8 = T. | last9 = Gnepp | first9 = DR. | title = Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. | journal = Am J Surg Pathol | volume = 35 | issue = 8 | pages = 1168-76 | month = Aug | year = 2011 | doi = 10.1097/PAS.0b013e31821e1f54 | PMID = 21716087 }} | ||
</ref> | </ref> | ||
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Image:Polymorphous_low-grade_adenocarcinoma_high_mag.jpg | PLGA - high mag. (WC/Nephron) | Image:Polymorphous_low-grade_adenocarcinoma_high_mag.jpg | PLGA - high mag. (WC/Nephron) | ||
</gallery> | </gallery> | ||
==IHC== | ==IHC== | ||
Features:<ref name=pmid23320410>{{Cite journal | last1 = de Araujo | first1 = VC. | last2 = Passador-Santos | first2 = F. | last3 = Turssi | first3 = C. | last4 = Soares | first4 = AB. | last5 = de Araujo | first5 = NS. | title = Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. | journal = Diagn Pathol | volume = 8 | issue = | pages = 6 | month = | year = 2013 | doi = 10.1186/1746-1596-8-6 | PMID = 23320410 }}</ref> | Features:<ref name=pmid23320410>{{Cite journal | last1 = de Araujo | first1 = VC. | last2 = Passador-Santos | first2 = F. | last3 = Turssi | first3 = C. | last4 = Soares | first4 = AB. | last5 = de Araujo | first5 = NS. | title = Polymorphous low-grade adenocarcinoma: an analysis of epidemiological studies and hints for pathologists. | journal = Diagn Pathol | volume = 8 | issue = | pages = 6 | month = | year = 2013 | doi = 10.1186/1746-1596-8-6 | PMID = 23320410 }}</ref> | ||