Difference between revisions of "Plasmacytoid urothelial carcinoma"
Jump to navigation
Jump to search
(+infobox) |
(+image) |
||
| Line 1: | Line 1: | ||
{{ Infobox diagnosis | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | | Name = {{PAGENAME}} | ||
| Image = | | Image = Plasmacytoid urothelial carcinoma -- very high mag.jpg | ||
| Width = | | Width = | ||
| Caption = | | Caption = Plasmacytoid urothelial carcinoma | ||
| Synonyms = plasmacytoid urothelial cell carcinoma | | Synonyms = plasmacytoid urothelial cell carcinoma, plasmacytoid variant of urothelial carcinoma | ||
| Micro = plasmacytoid morphology (abundant gray cytoplasm; eccentrically placed (usually round) nucleus), +/-mucous (common), usually with conventional urothelial carcinoma | | Micro = plasmacytoid morphology (abundant gray cytoplasm; eccentrically placed (usually round) nucleus), +/-mucous (common), usually with conventional urothelial carcinoma | ||
| Subtypes = subtype of [[urothelial carcinoma]] | | Subtypes = subtype of [[urothelial carcinoma]] | ||
| Line 30: | Line 30: | ||
| Tx = surgical excision, chemotherapy | | Tx = surgical excision, chemotherapy | ||
}} | }} | ||
'''Plasmacytoid urothelial carcinoma''', also '''plasmacytoid urothelial cell carcinoma''', is a rare aggressive variant of [[urothelial carcinoma]]. | '''Plasmacytoid urothelial carcinoma''', also '''plasmacytoid urothelial cell carcinoma''' and '''plasmacytoid variant of urothelial carcinoma''', is a rare aggressive variant of [[urothelial carcinoma]]. | ||
==General== | ==General== | ||
| Line 51: | Line 51: | ||
===Images=== | ===Images=== | ||
www: | |||
*[http://path.upmc.edu/cases/case267.html Plasmacytoid UCC - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case267.html Plasmacytoid UCC - several images (upmc.edu)]. | ||
<gallery> | |||
Image: Plasmacytoid urothelial carcinoma -- very low mag.jpg | Plasmacytoid UC - very low mag. | |||
Image: Plasmacytoid urothelial carcinoma -- low mag.jpg | Plasmacytoid UC - low mag. | |||
Image: Plasmacytoid urothelial carcinoma -- intermed mag.jpg | Plasmacytoid UC - intermed mag. | |||
Image: Plasmacytoid urothelial carcinoma - alt - intermed mag.jpg | Plasmacytoid UC - intermed mag. | |||
Image: Plasmacytoid urothelial carcinoma -- high mag.jpg | Plasmacytoid UC - high mag. | |||
Image: Plasmacytoid urothelial carcinoma -- very high mag.jpg | Plasmacytoid UC - very high mag. | |||
Image: Plasmacytoid urothelial carcinoma - alt -- very high mag.jpg | Plasmacytoid UC - very high mag. | |||
</gallery> | |||
==IHC== | ==IHC== | ||
Revision as of 17:51, 7 April 2015
| Plasmacytoid urothelial carcinoma | |
|---|---|
| Diagnosis in short | |
 Plasmacytoid urothelial carcinoma | |
|
| |
| Synonyms | plasmacytoid urothelial cell carcinoma, plasmacytoid variant of urothelial carcinoma |
|
| |
| LM | plasmacytoid morphology (abundant gray cytoplasm; eccentrically placed (usually round) nucleus), +/-mucous (common), usually with conventional urothelial carcinoma |
| Subtypes | subtype of urothelial carcinoma |
| LM DDx | plasma cell neoplasm, signet ring cell carcinoma, mucinous adenocarcinoma |
| IHC | AE1/AE3 +ve, EMA +ve, CK7 +ve, CK20 +ve, CD138 +ve, p63 +ve/-ve |
| Site | urothelium |
|
| |
| Signs | +/-hematuria |
| Prevalence | rare |
| Prognosis | poor |
| Treatment | surgical excision, chemotherapy |
Plasmacytoid urothelial carcinoma, also plasmacytoid urothelial cell carcinoma and plasmacytoid variant of urothelial carcinoma, is a rare aggressive variant of urothelial carcinoma.
General
Features:[1]
- Aggresive.
- Uncommon.
- Often associated with positive margins (relative to other urothelial carcinoma variants); spreads along fascial planes.[2]
Microscopic
Features:
- Plasmacytoid morphology:
- Abundant gray cytoplasm.
- Eccentric nucleus - usually round, occasionally crescentic.
- +/-Mucous (common).
DDx:
Images
www:
Plasmacytoid UC - very low mag.
Plasmacytoid UC - low mag.
Plasmacytoid UC - intermed mag.
Plasmacytoid UC - intermed mag.
Plasmacytoid UC - high mag.
Plasmacytoid UC - very high mag.
Plasmacytoid UC - very high mag.
IHC
Features:[3]
- AE1/AE3 +ve (16 +ve/16 cases).
- EMA +ve (16 +ve/16 cases).
- CK7 +ve (16 +ve/16 cases).
- CK20 +ve (16 +ve/16 cases).
- CD138 (15 +ve/16 cases).
- p63 (11 +ve/16 cases).
See also
References
- ↑ Qin, M.; Wang, G.; Sun, Y.; He, Q.. "Plasmacytoid urothelial carcinoma of the bladder.". Indian J Pathol Microbiol 57 (2): 320-2. doi:10.4103/0377-4929.134730. PMID 24943778.
- ↑ Kaimakliotis, HZ.; Monn, MF.; Cheng, L.; Masterson, TA.; Cary, KC.; Pedrosa, JA.; Foster, RS.; Koch, MO. et al. (May 2014). "Plasmacytoid bladder cancer: variant histology with aggressive behavior and a new mode of invasion along fascial planes.". Urology 83 (5): 1112-6. doi:10.1016/j.urology.2013.12.035. PMID 24582117.
- ↑ Zhang, W.; Jiang, YX.; Liu, Y.; Yu, WJ.; Zhao, H.; Li, YJ. (Jul 2013). "[Plasmacytoid urothelial carcinoma of the urinary bladder: a clinicopathologic study of 16 cases].". Zhonghua Bing Li Xue Za Zhi 42 (7): 433-7. PMID 24246859.