Placental alkaline phosphatase

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Placental alkaline phosphatase, abbreviated PLAP, is a common immunostain used for assessing suspected germ cell tumours.

Placental alkaline phosphatase
Immunostain in short

PLAP in germ cell neoplasia in situ - left of image. (WC)
Abbreviation PLAP
Similar stains OCT4, OCT3/4
Use germ cell tumours
Subspeciality genitourinary pathology, gynecologic pathology
Normal staining pattern membranous
Positive germ cell neoplasia in situ (previously ITGCN), seminoma, embryonal carcinoma
Negative normal testis, Sertoli cells only

It has largely been replaced by OCT4.




See also


  1. Hawkins, E.; Heifetz, SA.; Giller, R.; Cushing, B. (Apr 1997). "The prepubertal testis (prenatal and postnatal): its relationship to intratubular germ cell neoplasia: a combined Pediatric Oncology Group and Children's Cancer Study Group.". Hum Pathol 28 (4): 404-10. PMID 9104938.
  2. Schreiber, L.; Lifschitz-Mercer, B.; Paz, G.; Yavetz, H.; Elliott, DJ.; Kula, K.; Slowikowska-Hilczer, J.; Maymon, BB. (Jan 2003). "Double immunolabeling by the RBM and the PLAP markers for identifying intratubular (in situ) germ cell neoplasia of the testis.". Int J Surg Pathol 11 (1): 17-20. PMID 12598912.