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Difference between revisions of "Placenta"
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Note: There is no such thing as ''chorionitis''.<ref>ALS. February 2009.</ref> | Note: There is no such thing as ''chorionitis''.<ref>ALS. February 2009.</ref> | ||
==Infarction== | ==Infarction== | ||
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*Green/green discolourization. | *Green/green discolourization. | ||
===Microscopy<ref>ALS. 6 Feb 2009.</ref> | ===Microscopy=== | ||
Features:<ref>ALS. 6 Feb 2009.</ref> | |||
*Macrophages with brown fine granular pigment. | *Macrophages with brown fine granular pigment. | ||
*Columnar morphology (normally cuboidal). | *Columnar morphology (normally cuboidal). | ||
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*1-3 h - amnion is stained. | *1-3 h - amnion is stained. | ||
*>3 h - chorion is stained. | *>3 h - chorion is stained. | ||
DDx: | |||
*Hemosiderin-laden macrophages. | |||
Images: | Images: | ||
*[http://commons.wikimedia.org/wiki/File:Meconium-laden_macrophages_high_mag.jpg Meconium-laden macrophages - high mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Meconium-laden_macrophages_high_mag.jpg Meconium-laden macrophages - high mag. (WC)]. | ||
*[http://commons.wikimedia.org/wiki/File:Meconium-laden_macrophages_intermed_mag.jpg Meconium-laden macrophages - intermed. mag. (WC)]. | *[http://commons.wikimedia.org/wiki/File:Meconium-laden_macrophages_intermed_mag.jpg Meconium-laden macrophages - intermed. mag. (WC)]. | ||
===Special stains=== | ===Special stains=== | ||
*Hemosiderin +ve in hemosiderin-laden macrophages. | *Hemosiderin +ve in hemosiderin-laden macrophages. | ||
*PAS +ve in meconium-laden macrophages.<ref name=pmid11268705>{{cite journal |author=Povýsil C, Bennett R, Povýsilová V |title=CD 68 positivity of the so-called meconium corpuscles in human foetal intestine |journal=Cesk Patol |volume=37 |issue=1 |pages=7–9 |year=2001 |month=January |pmid=11268705 |doi= |url=}}</ref> | *PAS +ve in meconium-laden macrophages.<ref name=pmid11268705>{{cite journal |author=Povýsil C, Bennett R, Povýsilová V |title=CD 68 positivity of the so-called meconium corpuscles in human foetal intestine |journal=Cesk Patol |volume=37 |issue=1 |pages=7–9 |year=2001 |month=January |pmid=11268705 |doi= |url=}}</ref> | ||
Useful to differentiate hemosiderin-laden macrophages and meconium laden macrophages: | |||
*Hemosiderin stain -- +ve for old blood. | |||
**Prussian-blue stain = hemosiderin stain.<ref>{{cite journal |author=Sienko A, Altshuler G |title=Meconium-induced umbilical vascular necrosis in abortuses and fetuses: a histopathologic study for cytokines |journal=Obstet Gynecol |volume=94 |issue=3 |pages=415?0 |year=1999 |month=September |pmid=10472870 |doi= |url=}}</ref> | |||
*PAS-D -- +ve in chorioamnionitis??? | |||
Note: | |||
*Meconium contains bile.<ref>{{cite journal |author=Sienko A, Altshuler G |title=Meconium-induced umbilical vascular necrosis in abortuses and fetuses: a histopathologic study for cytokines |journal=Obstet Gynecol |volume=94 |issue=3 |pages=415?0 |year=1999 |month=September |pmid=10472870 |doi= |url=}}</ref> | |||
==Placental mass== | ==Placental mass== | ||