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Difference between revisions of "Placenta"
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*Associated with anti-phospholipid antibody (APLA) syndrome.<ref name=pmid12066949>{{cite journal |author=Sebire NJ, Backos M, Goldin RD, Regan L |title=Placental massive perivillous fibrin deposition associated with antiphospholipid antibody syndrome |journal=BJOG |volume=109 |issue=5 |pages=570–3 |year=2002 |month=May |pmid=12066949 |doi= |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1470-0328&date=2002&volume=109&issue=5&spage=570}}</ref> | *Associated with anti-phospholipid antibody (APLA) syndrome.<ref name=pmid12066949>{{cite journal |author=Sebire NJ, Backos M, Goldin RD, Regan L |title=Placental massive perivillous fibrin deposition associated with antiphospholipid antibody syndrome |journal=BJOG |volume=109 |issue=5 |pages=570–3 |year=2002 |month=May |pmid=12066949 |doi= |url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1470-0328&date=2002&volume=109&issue=5&spage=570}}</ref> | ||
**APLA is associated with recurrent miscarriage - can be treated with heparin + ASA.<ref name=pmid12066949/> | **APLA is associated with recurrent miscarriage - can be treated with heparin + ASA.<ref name=pmid12066949/> | ||
===Gross=== | |||
Features:<ref name=Ref_Placenta368>{{Ref Placenta|368}}</ref> | |||
*+/-Thickened placenta. | |||
*Maternal aspect of placental disc irregular or lobulated appearance. | |||
*+/-Yellowish discolourization. | |||
===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Fibrin deposition around villi on maternal aspect - see: ''[[Perivillous fibrin deposition]]''. | *Fibrin deposition around villi on maternal aspect - see: ''[[Perivillous fibrin deposition]]''. | ||
**Described as having a "net-like" pattern.<ref name=Ref_Placenta368>{{Ref Placenta|368}}</ref> | |||
DDx: | DDx: | ||
*[[Perivillous fibrin deposition]]. | *[[Perivillous fibrin deposition]] - less perivillous fibrin. | ||
*[[Placental infarction]]. | *[[Placental infarction]]. | ||
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*[http://www.flickr.com/photos/jian-hua_qiao_md/3986970923/ Maternal floor infarct (flickr.com)]. | *[http://www.flickr.com/photos/jian-hua_qiao_md/3986970923/ Maternal floor infarct (flickr.com)]. | ||
*[http://path.upmc.edu/cases/case224.html Maternal floor infarct - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case224.html Maternal floor infarct - several images (upmc.edu)]. | ||
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<pre> | |||
PLACENTA, UMBILICAL CORD AND FETAL MEMBRANES, BIRTH: | |||
- THREE VESSEL UMBILICAL CORD WITHIN NORMAL LIMITS. | |||
- FETAL MEMBRANES WITHIN NORMAL LIMITS. | |||
- SMALL PLACENTAL DISC WITH MASSIVE PERIVILLOUS FIBRIN DEPOSITION. | |||
</pre> | |||
=Fetal disease= | =Fetal disease= | ||