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Difference between revisions of "Pituitary gland"
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→Pituitary adenoma: +syndrome, tweak, wikify
(→General: +link to syndrome) |
(→Pituitary adenoma: +syndrome, tweak, wikify) |
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**Classically: visual field defects (bitemporal hemianopsia). | **Classically: visual field defects (bitemporal hemianopsia). | ||
**Others (increased intracranial pressure): headache, nausea, vomiting. | **Others (increased intracranial pressure): headache, nausea, vomiting. | ||
Classification: | Classification: | ||
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Notes: | Notes: | ||
*May be classified by what they secrete. ''Cushing disease'' is due to pituitary gland hypersecretion of ACTH (due to a pituitary adenoma ''or'' CRH hypersecretion from the hypothalamus).<ref name=Ref_PBoD8_1148>{{Ref PBoD8|1148}}</ref> [[Cushing syndrome]] is hypercortisolism ''not'' due to pituitary gland pathology. | *May be classified by what they secrete. ''Cushing disease'' is due to pituitary gland hypersecretion of ACTH (due to a pituitary adenoma ''or'' CRH hypersecretion from the hypothalamus).<ref name=Ref_PBoD8_1148>{{Ref PBoD8|1148}}</ref> [[Cushing syndrome]] is hypercortisolism ''not'' due to pituitary gland pathology. | ||
====Familial pituitary adenomas==== | |||
A pituitary adenoma may be part of a familial syndrome:<ref name=pmid19564887>{{Cite journal | last1 = Elston | first1 = MS. | last2 = McDonald | first2 = KL. | last3 = Clifton-Bligh | first3 = RJ. | last4 = Robinson | first4 = BG. | title = Familial pituitary tumor syndromes. | journal = Nat Rev Endocrinol | volume = 5 | issue = 8 | pages = 453-61 | month = Aug | year = 2009 | doi = 10.1038/nrendo.2009.126 | PMID = 19564887 }}</ref><ref name=Ref_PCPBoD8|554>{{Ref PCPBoD8|554}}</ref> | |||
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | |||
! Syndrome | |||
! Gene | |||
! Notes | |||
|- | |||
| [[Multiple endocrine neoplasia]] I | |||
| MEN1 | |||
| characterized by the 3 Ps: '''p'''ituitary adenoma, [[parathyroid adenoma|'''p'''arathyroid adenoma]], [[pancreatic neuroendocrine tumour|'''p'''ancreatic neuroendocrine tumour]] | |||
|- | |||
| MEN-1-like syndrome | |||
| CDKN1B<ref name=omim600778>{{OMIM|600778}}</ref> | |||
| known as ''Multiple endocrine neoplasia IV''<ref name=omim600778>{{OMIM|600778}}</ref> | |||
|- | |||
| [[Carney syndrome]] | |||
| PRKAR1A | |||
| | |||
|- | |||
| | |||
| AIP | |||
| classically GH-producing adenoma - lead to acromegaly | |||
|} | |||
===Microscopic=== | ===Microscopic=== | ||