Pituicytoma

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Pituicytoma is a neuropathology tumour in the [neurohypophysis.

General

Features:

  • Low-grade glial neoplasm originating in the neurohypophysis.

Grading:

  • WHO grade I.
  • ICD-O: 9432/1.

Gross

  • Adherent to other sellar structures.
  • Solid.
  • Well-circumscribed.

Microscopic

  • Solid compact growth pattern.
  • Bipolar spindle cells with distinctive cell borders.
  • Rare mitoses.
  • Few intercellular reticulin.

IHC

  • GFAP: variable.
  • S-100+ve.
  • EMA: patchy.
  • TTF1+ve.
  • Synaptophysin -ve.
  • Mib-1: low.

DDx:

  • Pilocytic astrocytoma (Rosenthal fibers, eosinophilic granular bodies)
  • Normal neurohypophysis
  • Spindle cell oncocytoma

Images

Note: It is thoought that Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.[1]


See also

References

  1. Mete, O.; Lopes, MB.; Asa, SL. (Nov 2013). "Spindle cell oncocytomas and granular cell tumors of the pituitary are variants of pituicytoma.". Am J Surg Pathol 37 (11): 1694-9. doi:10.1097/PAS.0b013e31829723e7. PMID 23887161.