Difference between revisions of "Pilomyxoid astrocytoma"

From Libre Pathology
Jump to navigation Jump to search
(split out)
Line 12: Line 12:
==Gross==
==Gross==
Features:<ref name=Ref_PSNP86>{{Ref PSNP|86}}</ref>
Features:<ref name=Ref_PSNP86>{{Ref PSNP|86}}</ref>
*Classically - hypothalamic location/suprasellar location; may involve the sella turcica.<ref name=pmid19766001>{{cite journal |author=Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A |title=Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent |journal=J Clin Neurosci |volume=16 |issue=12 |pages=1648–9 |year=2009 |month=December |pmid=19766001 |doi=10.1016/j.jocn.2009.01.035 |url=}}</ref>
*Classically - hypothalamic location/suprasellar location; may involve the [[sella turcica]].<ref name=pmid19766001>{{cite journal |author=Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A |title=Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent |journal=J Clin Neurosci |volume=16 |issue=12 |pages=1648–9 |year=2009 |month=December |pmid=19766001 |doi=10.1016/j.jocn.2009.01.035 |url=}}</ref>
*Solid.
*Solid.
*Well-circumscribed.
*Well-circumscribed.

Revision as of 06:03, 10 December 2014

Pilomyxoid astrocytoma is a neuropathology tumour related to pilocytic astrocytoma.

General

Features:[1]

  • A variant of pilocytic astrocytoma.
    • Some have suggested it is a unique entity.[2]
  • Childhood or adolescence.

Grading:

  • WHO Grade II by definition.[1]

Gross

Features:[1]

  • Classically - hypothalamic location/suprasellar location; may involve the sella turcica.[3]
  • Solid.
  • Well-circumscribed.

Microscopic

Features:[1]

  • Consists of small round/ovoid bland cells in a myxoid stroma.
  • Hair-like fibres ~ 1 micrometer.
    • Often difficult to appreciate on standard (H&E) histologic sections.
  • Usually angiocentric (surround blood vessel) - key feature.

Notes:[1]

  • Rosenthal fibres are absent - key negative.
  • Monophasic (unlike classical pilocytic astrocytomas) - key negative.
  • May rarely have eosinophilic granular bodies.

Images

See also

References

  1. 1.0 1.1 1.2 1.3 1.4 Perry, Arie; Brat, Daniel J. (2010). Practical Surgical Neuropathology: A Diagnostic Approach: A Volume in the Pattern Recognition series (1st ed.). Churchill Livingstone. pp. 86. ISBN 978-0443069826.
  2. Komotar RJ, Mocco J, Jones JE, et al. (June 2005). "Pilomyxoid astrocytoma: diagnosis, prognosis, and management". Neurosurg Focus 18 (6A): E7. PMID 16048293.
  3. Alimohamadi M, Bidabadi MS, Ayan Z, Ketabchi E, Amirjamshidi A (December 2009). "Pilomyxoid astrocytoma with involvement of the sella turcica in an adolescent". J Clin Neurosci 16 (12): 1648–9. doi:10.1016/j.jocn.2009.01.035. PMID 19766001.