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Difference between revisions of "Phyllodes tumour"
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| Caption = Phyllodes tumour. [[H&E stain]]. | | Caption = Phyllodes tumour. [[H&E stain]]. | ||
| Synonyms = | | Synonyms = | ||
| Micro = either (1) or (2): (1) large slit-like spaces, (2) cellular stroma - may be myxoid; +/-infiltrative border, +/-mitoses, +/-nuclear atypia, +/-"stromal overgrowth" ~ stroma fills microscopic field | | Micro = either (1) or (2): (1) large slit-like spaces, (2) cellular stroma - may be myxoid; +/-infiltrative border, +/-mitoses, +/-nuclear atypia, +/-"stromal overgrowth" ~ stroma fills microscopic field (see ''microscopic'' section) | ||
| Subtypes = benign, borderline, malignant | | Subtypes = benign, borderline, malignant | ||
| LMDDx = [[fibroadenoma]], [[metaplastic breast carcinoma]], primary breast sarcoma, other [[sarcoma]]s | | LMDDx = [[fibroadenoma]], [[metaplastic breast carcinoma]], primary breast sarcoma, other [[sarcoma]]s | ||
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'''Phyllodes tumour''' is a tumour of the intralobular breast stroma. It may be benign or [[malignant]]. | '''Phyllodes tumour''' is a tumour of the intralobular breast stroma. It may be benign or [[malignant]]. | ||
It was previously called '''cystosarcoma phyllodes'''. | It was previously called '''cystosarcoma phyllodes'''. It is a type of [[fibroepithelial tumours of the breast|fibroepithelial tumour]]. | ||
==General== | ==General== | ||
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Image:Phyllodes_tumour_-_very_low_mag.jpg | Phyllodes tumour - very low mag. (WC/Nephron) | Image:Phyllodes_tumour_-_very_low_mag.jpg | Phyllodes tumour - very low mag. (WC/Nephron) | ||
Image:Phyllodes_tumour_-_low_mag.jpg | Phyllodes tumour - low mag. (WC/Nephron) | Image:Phyllodes_tumour_-_low_mag.jpg | Phyllodes tumour - low mag. (WC/Nephron) | ||
Image:Malignant phyllodes tumour.jpg |Malignant phyllodes tumour - low mag (WC) | |||
Image:Malignant phyllodes tumour high magnification.jpg |Malignant phyllodes tumour - high mag (WC) | |||
</gallery> | </gallery> | ||
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* † Stromal overgrowth = epithelial elements absent in one low power field (LPF), defined as x40;<ref name=pmid17932112>{{cite journal |author=Taira N, Takabatake D, Aogi K, ''et al'' |title=Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin |journal=Jpn. J. Clin. Oncol. |volume=37 |issue=10 |pages=730-6 |year=2007 |month=October |pmid=17932112 |doi=10.1093/jjco/hym099 |url=http://jjco.oxfordjournals.org/cgi/reprint/37/10/730}}</ref> ''LPF'' is not adequately defined - see [[LPFitis]]. | * † Stromal overgrowth = epithelial elements absent in one low power field (LPF), defined as x40;<ref name=pmid17932112>{{cite journal |author=Taira N, Takabatake D, Aogi K, ''et al'' |title=Phyllodes tumor of the breast: stromal overgrowth and histological classification are useful prognosis-predictive factors for local recurrence in patients with a positive surgical margin |journal=Jpn. J. Clin. Oncol. |volume=37 |issue=10 |pages=730-6 |year=2007 |month=October |pmid=17932112 |doi=10.1093/jjco/hym099 |url=http://jjco.oxfordjournals.org/cgi/reprint/37/10/730}}</ref> ''LPF'' is not adequately defined - see [[LPFitis]]. | ||
* ‡ ''HPF'' is not adequately defined - see [[HPFitis]]. | * ‡ ''HPF'' is not adequately defined - see [[HPFitis]]. | ||
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===Benign=== | |||
<pre> | |||
Right Breast Mass, Excision: | |||
- Benign phyllodes tumour. | |||
- NEGATIVE for malignancy. | |||
</pre> | |||
====Micro==== | |||
The sections show a well-circumscribed mass with a leaf-like architecture. There is no stromal overgrowth or atypia. Proliferative activity is not readily apparent. | |||
==See also== | ==See also== | ||