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Difference between revisions of "Peutz-Jeghers polyp"
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| Assdx = | | Assdx = | ||
| Syndromes = [[Peutz-Jeghers syndrome]] | | Syndromes = [[Peutz-Jeghers syndrome]] | ||
| Clinicalhx = family history of cancer - esp. [[ | | Clinicalhx = family history of cancer - esp. gastrointestinal and [[breast cancer|breast]] | ||
| Signs = | | Signs = | ||
| Symptoms = | | Symptoms = | ||
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| Rads = | | Rads = | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign lesion; suggests | | Prognosis = benign lesion; suggests increased malignancy risk | ||
| Other = | | Other = | ||
| ClinDDx = other [[gastrointestinal polyps]] | | ClinDDx = other [[gastrointestinal polyps]] | ||
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| pathoutlines = | | pathoutlines = | ||
}} | }} | ||
'''Peutz-Jeghers polyp''' is an uncommon gastrointestinal polyp. It is usually associated with [[Peutz-Jeghers syndrome]]. | '''Peutz-Jeghers polyp''', abbreviated '''PJP''', is an uncommon [[hamartoma|hamartomous]] [[gastrointestinal polyp]]. It is usually associated with [[Peutz-Jeghers syndrome]]. | ||
==General== | ==General== | ||
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**The '''key''' is "thick" smooth muscle bundles - if one is lucky one sees branching.<ref>C. Streutker. 26 July 2011.</ref> | **The '''key''' is "thick" smooth muscle bundles - if one is lucky one sees branching.<ref>C. Streutker. 26 July 2011.</ref> | ||
***"Thick" ~= thickness of muscularis mucosae. | ***"Thick" ~= thickness of muscularis mucosae. | ||
DDx: | |||
*[[Hyperplastic polyp of the stomach]] - should ''not'' have thickened muscle. | |||
**May be confused with PJP as branching may not be apparent. | |||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Peutz-Jeghers_syndrome_polyp.jpg | Peutz-Jeghers polyp - intestine (WC/Nephron) | Image:Peutz-Jeghers_syndrome_polyp.jpg | Peutz-Jeghers polyp - intestine (WC/Nephron) | ||
</gallery> | </gallery> | ||
<gallery> | |||
Image:Gastric_Peutz-Jeghers_polyp_-_very_low_mag.jpg | Peutz-Jeghers polyp - stomach - very low mag. (WC/Nephron) | |||
Image: Gastric Peutz-Jeghers polyp - low mag.jpg | Peutz-Jeghers polyp - stomach - low mag. (WC/Nephron) | |||
Image: Gastric Peutz-Jeghers polyp - intermed mag.jpg | Peutz-Jeghers polyp - stomach - intermed. mag. (WC/Nephron) | |||
</gallery> | |||
<gallery> | |||
Image:Colon histology with Peutz-Jeghers polyp.jpg | Peutz-Jeghers (colonic) polyp (WC) | |||
</gallery> | |||
==IHC== | |||
*[[Chromogranin A]] - increased staining in relation to background; increased enterochromaffin cells.<ref name=pmid24364221>{{Cite journal | last1 = Krstić | first1 = M. | last2 = Katić | first2 = V. | last3 = Stojnev | first3 = S. | last4 = Mihailović | first4 = D. | last5 = Mojsilović | first5 = M. | last6 = Radovanović | first6 = Z. | last7 = Zivković | first7 = V. | title = Peutz-Jeghers syndrome: quantitative study on enterochromaffin cells in hamartomatous intestine polyps. | journal = Srp Arh Celok Lek | volume = 141 | issue = 9-10 | pages = 602-7 | month = | year = | doi = | PMID = 24364221 }}</ref> | |||
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