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Difference between revisions of "Peripheral nerve sheath tumours"
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Peripheral nerve sheath tumours (view source)
Revision as of 16:33, 2 September 2011
, 16:33, 2 September 2011→Traumatic neuroma: +palisaded and encapsulated neuroma
(→Traumatic neuroma: +palisaded and encapsulated neuroma) |
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Features: | Features: | ||
*Nerve with adjacent small organized micro-fascicles in collagen - as seen in regeneration. | *Nerve with adjacent small organized micro-fascicles in collagen - as seen in regeneration. | ||
==Palisaded encapsulated neuroma== | |||
*Abbreviated ''PEN''. | |||
*[[AKA]] ''palisaded and encapsulated neuroma''. | |||
===General=== | |||
*Flesh-colour papule - classically on the face.<ref name=Ref_Derm536>{{Ref Derm|536}}</ref> | |||
*Isolated finding - not associated with a systemic disease or malignancy.<ref name=pmid18718196>{{Cite journal | last1 = Newman | first1 = MD. | last2 = Milgraum | first2 = S. | title = Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor. | journal = Dermatol Online J | volume = 14 | issue = 7 | pages = 12 | month = | year = 2008 | doi = | PMID = 18718196 }}</ref> | |||
===Microscopic=== | |||
Features:<ref name=Ref_Derm536>{{Ref Derm|536}}</ref> | |||
*Encapsulated dermal spindle cell lesion. | |||
**Fasciular arrangement. | |||
DDx: | |||
*[[Schwannoma]]. | |||
Other considerations: | |||
*[[Leiomyoma]] - cytoplasm not vacuolated, nuclei more elliptical. | |||
Images: | |||
*[http://dermatology.cdlib.org/147/case_presentation/pen/2.jpg PEN (cdlib.org)].<ref name=pmid18718196>{{Cite journal | last1 = Newman | first1 = MD. | last2 = Milgraum | first2 = S. | title = Palisaded encapsulated neuroma (PEN): an often misdiagnosed neural tumor. | journal = Dermatol Online J | volume = 14 | issue = 7 | pages = 12 | month = | year = 2008 | doi = | PMID = 18718196 }}</ref> | |||
===IHC=== | |||
Features:<ref name=pmid18718196/> | |||
*S100 +ve. | |||
*EMA +ve (capsule of lesion). | |||
==Neurofibroma== | ==Neurofibroma== | ||