30
edits
Difference between revisions of "Pediatric gastrointestinal pathology"
Jump to navigation
Jump to search
m
Pediatric gastrointestinal pathology (view source)
Revision as of 18:35, 6 May 2018
, 18:35, 6 May 2018→Images
(→Gross) |
m (→Images) |
||
| (9 intermediate revisions by 2 users not shown) | |||
| Line 136: | Line 136: | ||
*Short-segment (75-80%): Rectum, distal sigmoid | *Short-segment (75-80%): Rectum, distal sigmoid | ||
*Long-segment HD (10-20%): Beyond splenic flexure | *Long-segment HD (10-20%): Beyond splenic flexure | ||
*Total colonic aganglionosis (5-15%): Entire colon | *Total colonic aganglionosis (5-15%): Entire colon.<ref name=pmid25395999>{{Cite web | last = | first = | title = Diagnosis of Hirschsprung's disease with particular emphasis on histopathology. A systematic review of current literature | url = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223113/ | publisher = | date = | accessdate = 19 August 2017 }}</ref> | ||
**[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223113/figure/F0001/ Classification of Hirschsprung's disease according to the aganglionic segment length (https://www.ncbi.nlm.nih.gov)] | **[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223113/figure/F0001/ Classification of Hirschsprung's disease according to the aganglionic segment length (https://www.ncbi.nlm.nih.gov)] | ||
| Line 146: | Line 146: | ||
Features: | Features: | ||
*Ganglion cells missing in submucosal plexus and myenteric plexus. | *Ganglion cells missing in submucosal plexus and myenteric plexus. | ||
**Increasing ganglia proximally into transition zone | |||
*Hypertrophy of neural plexuses. | |||
**Many nerve trunks > 40 μm | |||
*Abnormal submucosal blood vessels may be seen | |||
*+/-Submucosal fibrosis. | *+/-Submucosal fibrosis. | ||
| Line 164: | Line 168: | ||
**Nerve fibres +ve control. | **Nerve fibres +ve control. | ||
Others | Others<ref>{{Cite book | last1 = Lin | first1 = Fan | last2 = Prichard | first2 = Jeffrey | title = Handbook of practical immunohistochemistry : frequently asked question | date = | publisher = | location = | isbn = 9781493915774 | pages = }}</ref> | ||
* | : | ||
* | *Calretinin ~ -ve, Usually negative in hypertrophied nerve fibers in Hirschsprung’s disease, superior to acetylcholinesterase. | ||
*NSE ~ -ve, Highlights ganglion cells to exclude Hirschsprung’s disease; specific but not very sensitive. | |||
==Meconium ileus== | ==Meconium ileus== | ||
| Line 221: | Line 226: | ||
Images: | Images: | ||
*[http://en.wikipedia.org/wiki/File:Neonatal_necrotizing_enterocolitis,_gross_pathology_20G0021_lores.jpg NEC - gross (WP)]. | *[http://en.wikipedia.org/wiki/File:Neonatal_necrotizing_enterocolitis,_gross_pathology_20G0021_lores.jpg NEC - gross (WP)]. | ||
*[ | *[https://library.med.utah.edu/WebPath/PEDHTML/PED045.html NEC - micro]. | ||
==Autoimmune enteropathy== | ==Autoimmune enteropathy== | ||
| Line 268: | Line 273: | ||
====Images==== | ====Images==== | ||
==Biliary atresia== | ==Biliary atresia== | ||