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Difference between revisions of "Pediatric-type diffuse high-grade glioma"
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Pediatric-type diffuse high-grade glioma (view source)
Revision as of 09:31, 5 April 2022
, 09:31, 5 April 2022→Diffuse hemispheric glioma, H3 G34-mutant: +ref
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* Up to 15% of all hemispheric pediatric gliomas. | * Up to 15% of all hemispheric pediatric gliomas. | ||
* Highly cellular tumor often with microvascular proliferation and necrosis. | * Highly cellular tumor often with microvascular proliferation and necrosis. | ||
* May resemble embryonal tumours (important DDx). | * May resemble embryonal tumours (important DDx).<ref name="pmid26482474">Korshunov A, Capper D, Reuss D, Schrimpf D, Ryzhova M, Hovestadt V | display-authors=etal (2016) [https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=26482474 Histologically distinct neuroepithelial tumors with histone 3 G34 mutation are molecularly similar and comprise a single nosologic entity.] ''Acta Neuropathol'' 131 (1):137-46. [http://dx.doi.org/10.1007/s00401-015-1493-1 DOI:10.1007/s00401-015-1493-1] PMID: [https://pubmed.gov/26482474 26482474]</ref> | ||
* IHC: MAP2+ve, TP53+ve, Olig2-ve, ATRX loss. | * IHC: MAP2+ve, TP53+ve, Olig2-ve, ATRX loss. | ||
* H3F3A G43R or G34V mutation present. | * H3F3A G43R or G34V mutation present. | ||