Difference between revisions of "Parachordoma"

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'''Parachordoma''' is a very rare paraspinal tumour that is similar to [[chordoma]].<ref name=pmid10809219>{{cite journal |author=Fisher C |title=Parachordoma exists--but what is it? |journal=Adv Anat Pathol |volume=7 |issue=3 |pages=141–8 |year=2000 |month=May |pmid=10809219 |doi= |url=}}</ref>
'''Parachordoma''' is a very rare paraspinal tumour that is similar to [[chordoma]].<ref name=pmid10809219>{{cite journal |author=Fisher C |title=Parachordoma exists--but what is it? |journal=Adv Anat Pathol |volume=7 |issue=3 |pages=141–8 |year=2000 |month=May |pmid=10809219 |doi= |url=}}</ref>


==General==
*Super rare - only approximately 30 cases reported.<ref name=pmid10478665/>


==Microscopic==
Features:<ref name=pmid10478665/>
*Multivacuolated cells (physaliferous cell-like) - '''key feature'''.
**May be rare.
*"Large" rounded eosinophilic cells - '''important'''.
*Variable matrix:
**Myxoid.
**Dense appearing hyaline - [[cartilage]]-like.
*Small cells (spindled and rounded) - common.
DDx:
*[[Chordoma]].
*[[Extraskeletal myxoid chondrosarcoma]].
==Stains==
*Alcian blue +ve (matrix).<ref name=pmid10478665/>


==IHC==
==IHC==
<ref name=pmid10478665>{{Cite journal | last1 = Folpe| first1 = AL.| last2 = Agoff| first2 = SN.| last3 = Willis| first3 = J.| last4 = Weiss| first4 = SW.| title = Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma.| journal = Am J Surg Pathol| volume = 23| issue = 9| pages = 1059-67| month = Sep| year = 1999| doi = | PMID = 10478665 }}</ref>  
Features:<ref name=pmid10478665>{{Cite journal | last1 = Folpe| first1 = AL.| last2 = Agoff| first2 = SN.| last3 = Willis| first3 = J.| last4 = Weiss| first4 = SW.| title = Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma.| journal = Am J Surg Pathol| volume = 23| issue = 9| pages = 1059-67| month = Sep| year = 1999| doi = | PMID = 10478665 }}</ref>  
*CK 8/18 +ve.
*EMA +ve.
*S-100 +ve.
*Vimentin +ve.
 
Note:
*Other keratins negative.
 
==See also==
*[[Chordoma]].


==References==
==References==

Revision as of 03:24, 30 December 2013

Parachordoma is a very rare paraspinal tumour that is similar to chordoma.[1]

General

  • Super rare - only approximately 30 cases reported.[2]

Microscopic

Features:[2]

  • Multivacuolated cells (physaliferous cell-like) - key feature.
    • May be rare.
  • "Large" rounded eosinophilic cells - important.
  • Variable matrix:
    • Myxoid.
    • Dense appearing hyaline - cartilage-like.
  • Small cells (spindled and rounded) - common.

DDx:

Stains

  • Alcian blue +ve (matrix).[2]

IHC

Features:[2]

  • CK 8/18 +ve.
  • EMA +ve.
  • S-100 +ve.
  • Vimentin +ve.

Note:

  • Other keratins negative.

See also

References

  1. Fisher C (May 2000). "Parachordoma exists--but what is it?". Adv Anat Pathol 7 (3): 141–8. PMID 10809219.
  2. 2.0 2.1 2.2 2.3 Folpe, AL.; Agoff, SN.; Willis, J.; Weiss, SW. (Sep 1999). "Parachordoma is immunohistochemically and cytogenetically distinct from axial chordoma and extraskeletal myxoid chondrosarcoma.". Am J Surg Pathol 23 (9): 1059-67. PMID 10478665.