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Difference between revisions of "Papillary thyroid carcinoma"
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Papillary thyroid carcinoma (view source)
Revision as of 12:10, 30 March 2015
, 12:10, 30 March 2015→Microscopic
| Line 167: | Line 167: | ||
*Morules - interspersed balls of squamoid cells | *Morules - interspersed balls of squamoid cells | ||
**no keritinization or intercellular bridges. | **no keritinization or intercellular bridges. | ||
**Homogenous, lightly eosinophilic glassy nuclei | **Homogenous, lightly eosinophilic glassy nuclei. | ||
. | |||
*Follicles | *Follicles | ||
**Cribriform, papillary, trabecular and solid patterns. | **Cribriform, papillary, trabecular and solid patterns. | ||
| Line 174: | Line 173: | ||
**Little colloid | **Little colloid | ||
**Papillary carcinoma nuclear features. | **Papillary carcinoma nuclear features. | ||
<gallery> | <gallery> | ||
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Image:Thyroid PapillaryCarcinoma CribriformMorularVariant betaCatenin HP 13BR***.jpg|Thyroid - Papillary Carcinoma Cribriform Morular Variant - beta catenin (SKB) | Image:Thyroid PapillaryCarcinoma CribriformMorularVariant betaCatenin HP 13BR***.jpg|Thyroid - Papillary Carcinoma Cribriform Morular Variant - beta catenin (SKB) | ||
</gallery> | </gallery> | ||
IHC: | |||
CDX2 - Highlights the morules (CDX2 is positive in the biotin rich nuclei associated with morule formation in a variety of situations)<ref>{{Cite journal | last1 = Wani | first1 = Y. | last2 = Notohara | first2 = K. | last3 = Nakatani | first3 = Y. | last4 = Matsuzaki | first4 = A. | title = Aberrant nuclear Cdx2 expression in morule-forming tumours in different organs, accompanied by cytoplasmic reactivity. | journal = Histopathology | volume = 55 | issue = 4 | pages = 465-8 | month = Oct | year = 2009 | doi = 10.1111/j.1365-2559.2009.03382.x | PMID = 19817898 }}</ref> | |||
DDX: | |||
*Papillary thyroid carcinoma | |||
*Papillary thyroid carcinoma, tall cell variant | |||
====Papillary thyroid carcinoma diffuse sclerosing variant==== | ====Papillary thyroid carcinoma diffuse sclerosing variant==== | ||