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Difference between revisions of "Pancreas"
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→Ductual adenoarcinomas: +PanIN section
(→Pancreas neoplasms in a table: precursor) |
(→Ductual adenoarcinomas: +PanIN section) |
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| Line 373: | Line 373: | ||
*Cystadenoma. | *Cystadenoma. | ||
*Cystadenocarcinoma. | *Cystadenocarcinoma. | ||
==Pancreatic intraepithelial neoplasia (PanIN)== | |||
*PanIN is thought to be the precursor lesion for pancreatic carcinoma.<ref>PBoD P.949.</ref> | |||
===Overview=== | |||
Putative preneoplasm-neoplasm-carcinoma sequence: | |||
*PanIN1a. | |||
**Not neoplastic, i.e. colonal. | |||
*PanIN1b. | |||
**Not neoplastic, i.e. colonal. | |||
*PanIN2. | |||
**Can be thought of as ''low-grade dysplasia'', e.g. a ''(colonic) tubular adenoma without high-grade dysplasia''. | |||
*PanIN3. | |||
**Can be thought of as ''high-grade dysplasia'', e.g. ''(colonic) villous adenoma''. | |||
===Histomorphology=== | |||
Features:<ref>PBoD P.949.</ref> | |||
*PanIN1a - increased amount of cytoplasm. | |||
**Nuclear size & stratification perserved, arch. perserved. | |||
*PanIN1b - increased amount of cytoplasm, folding of epithelium/moderated arch. distortion. | |||
**Nuclear size & stratification perserved. | |||
*PanIN2 - increased cell size, and nuclear enlargement (increased NC ratio), moderate nuclear atypia with loss of (basal) nuclear polarization. | |||
*PanIN3 - marked nuclear atypia with increased NC ratio. | |||
**No invasion identified. | |||
*Pancreatic carcinoma - cytologic features of PanIN3 with definite invasion. | |||
Image: [http://commons.wikimedia.org/wiki/File:Pancreas_neoplasia_carcinoma_sequence.png Normal pancreas, pancreatic intraepithelial neoplasia and pancreatic carcinoma (WC)]. | |||
==Ductual adenoarcinomas== | ==Ductual adenoarcinomas== | ||