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Features of adenocarcinoma:<ref name=pmid16273946>{{Cite journal | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi = | PMID = 16273946 }}</ref> | Features of adenocarcinoma:<ref name=pmid16273946>{{Cite journal | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi = | PMID = 16273946 }}</ref> | ||
*Random distribution of ductal structures | *Ductal architecture: | ||
*Irregular ductal contours | **Random distribution of ductal structures. | ||
**Irregular ductal contours. | |||
**"Naked ducts in fat"; ducts without surrounding pancreatic elements or fibrous tissue. | |||
**Ducts adjacent to arterioles. | |||
*Nuclear atypia: | *Nuclear atypia: | ||
**Enlargement (>3 times the size of a lymphocyte). | **Enlargement (>3 times the size of a lymphocyte). | ||
**Pleomorphism. | **Pleomorphism. | ||
**Distinct nucleoli. | **Distinct nucleoli. | ||
* | **Hyperchromatic raisinoid nucleoli. | ||
*Hyperchromatic raisinoid nucleoli | |||
*Generally assoc. with malignancy: | *Generally assoc. with malignancy: | ||
**Perineural and vascular invasion (rare). | **Perineural and vascular invasion (rare). | ||
**Mitosis. | **Mitosis. | ||
**Necrotic cellular debris (intraluminal). | |||
==See also== | ==See also== |
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