Difference between revisions of "Pancreas"

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Features of adenocarcinoma:<ref name=pmid16273946>{{Cite journal  | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi =  | PMID = 16273946 }}</ref>
Features of adenocarcinoma:<ref name=pmid16273946>{{Cite journal  | last1 = Adsay | first1 = NV. | last2 = Bandyopadhyay | first2 = S. | last3 = Basturk | first3 = O. | last4 = Othman | first4 = M. | last5 = Cheng | first5 = JD. | last6 = Klöppel | first6 = G. | last7 = Klimstra | first7 = DS. | title = Chronic pancreatitis or pancreatic ductal adenocarcinoma? | journal = Semin Diagn Pathol | volume = 21 | issue = 4 | pages = 268-76 | month = Nov | year = 2004 | doi =  | PMID = 16273946 }}</ref>
*Random distribution of ductal structures,
*Ductal architecture:
*Irregular ductal contours,
**Random distribution of ductal structures.
**Irregular ductal contours.
**"Naked ducts in fat"; ducts without surrounding pancreatic elements or fibrous tissue.
**Ducts adjacent to arterioles.
*Nuclear atypia:
*Nuclear atypia:
**Enlargement (>3 times the size of a lymphocyte).  
**Enlargement (>3 times the size of a lymphocyte).  
**Pleomorphism.  
**Pleomorphism.  
**Distinct nucleoli.
**Distinct nucleoli.
*Intraluminal necrotic cellular debris.
**Hyperchromatic raisinoid nucleoli.  
*Hyperchromatic raisinoid nucleoli.
*"Naked ducts in fat"; ducts without surrounding pancreatic elements or fibrous tissue.
*Ducts adjacent to arterioles.  
*Generally assoc. with malignancy:
*Generally assoc. with malignancy:
**Perineural and vascular invasion (rare).
**Perineural and vascular invasion (rare).
**Mitosis.
**Mitosis.
**Necrotic cellular debris (intraluminal).


==See also==
==See also==
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