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Difference between revisions of "Paired box gene 8"
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→Negative staining: +mesothelioma
m (PAX8 polyclonal antibodies can cross react with PAX5 = false positive) |
(→Negative staining: +mesothelioma) |
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| Line 27: | Line 27: | ||
**Can help differentiate from lung NETs. | **Can help differentiate from lung NETs. | ||
*Epithelial component of thymic tumors 77-100% depending on sub-type<ref name=pmid21552115/><ref name=pmid21836478>{{cite journal |vauthors=Weissferdt A, Moran CA |title=Pax8 expression in thymic epithelial neoplasms: an immunohistochemical analysis |journal=Am. J. Surg. Pathol. |volume=35 |issue=9 |pages=1305–10 |date=September 2011 |pmid=21836478 |doi=10.1097/PAS.0b013e3182260735 |url=}}</ref> | *Epithelial component of thymic tumors 77-100% depending on sub-type<ref name=pmid21552115/><ref name=pmid21836478>{{cite journal |vauthors=Weissferdt A, Moran CA |title=Pax8 expression in thymic epithelial neoplasms: an immunohistochemical analysis |journal=Am. J. Surg. Pathol. |volume=35 |issue=9 |pages=1305–10 |date=September 2011 |pmid=21836478 |doi=10.1097/PAS.0b013e3182260735 |url=}}</ref> | ||
===May be positive=== | |||
*Peritoneal [[malignant mesothelioma]] (5 +ve of 27<ref name=pmid28877056>{{cite journal |vauthors=Chapel DB, Husain AN, Krausz T, McGregor SM |title=PAX8 Expression in a Subset of Malignant Peritoneal Mesotheliomas and Benign Mesothelium has Diagnostic Implications in the Differential Diagnosis of Ovarian Serous Carcinoma |journal=Am. J. Surg. Pathol. |volume=41 |issue=12 |pages=1675–1682 |date=December 2017 |pmid=28877056 |doi=10.1097/PAS.0000000000000935 |url=}}</ref>). | |||
==Negative staining== | ==Negative staining== | ||