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Difference between revisions of "Paired box gene 8"
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PAX8 polyclonal antibodies can cross react with PAX5 = false positive
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[[Image:Lymphoma - lung - PAX8 -- intermed mag.jpg|thumb|right|300px|Negative PAX8 staining in a lymphoma.]] | [[Image:Lymphoma - lung - PAX8 -- intermed mag.jpg|thumb|right|300px|Negative PAX8 staining in a lymphoma.]] | ||
*[[Urothelial carcinoma]] - can be positive (3 positive/18 bladder tumours<ref name=pmid21552115/>). | *[[Urothelial carcinoma]] - can be positive (3 positive/18 bladder tumours<ref name=pmid21552115/>). | ||
*[[Lymphoma]]. | *[[Lymphoma]] (beware false positive staining due to polyclonal PAX8 antibodies cross-reacting with PAX5)<ref name=pmid22037256>{{cite journal |vauthors=Moretti L, Medeiros LJ, Kunkalla K, Williams MD, Singh RR, Vega F |title=N-terminal PAX8 polyclonal antibody shows cross-reactivity with N-terminal region of PAX5 and is responsible for reports of PAX8 positivity in malignant lymphomas |journal=Mod. Pathol. |volume=25 |issue=2 |pages=231–6 |date=February 2012 |pmid=22037256 |doi=10.1038/modpathol.2011.162 |url=}}</ref> | ||
*[[Malignant melanoma]].<ref name=pmid21285870>{{Cite journal | last1 = Tacha | first1 = D. | last2 = Zhou | first2 = D. | last3 = Cheng | first3 = L. | title = Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study. | journal = Appl Immunohistochem Mol Morphol | volume = 19 | issue = 4 | pages = 293-9 | month = Jul | year = 2011 | doi = 10.1097/PAI.0b013e3182025f66 | PMID = 21285870 }}</ref> | *[[Malignant melanoma]].<ref name=pmid21285870>{{Cite journal | last1 = Tacha | first1 = D. | last2 = Zhou | first2 = D. | last3 = Cheng | first3 = L. | title = Expression of PAX8 in normal and neoplastic tissues: a comprehensive immunohistochemical study. | journal = Appl Immunohistochem Mol Morphol | volume = 19 | issue = 4 | pages = 293-9 | month = Jul | year = 2011 | doi = 10.1097/PAI.0b013e3182025f66 | PMID = 21285870 }}</ref> | ||