653
edits
(+infobox) |
|||
(5 intermediate revisions by 2 users not shown) | |||
Line 19: | Line 19: | ||
| Syndromes = | | Syndromes = | ||
| Clinicalhx = | | Clinicalhx = | ||
| Signs = deafness | | Signs = +/-deafness | ||
| Symptoms = bone pain | | Symptoms = +/-bone pain | ||
| Prevalence = | | Prevalence = | ||
| Bloodwork = elevated ALP | | Bloodwork = elevated ALP | ||
Line 69: | Line 69: | ||
==Microscopic== | ==Microscopic== | ||
Features:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref> | Features:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref> | ||
*Lytic and mixed Paget disease are cellular and fibro-osseous (bone and fibrous components) | |||
*Sclerotic Paget disease has thickened bone trabeculae. | |||
*Bone matrix has jigsaw-puzzle like pattern. | *Bone matrix has jigsaw-puzzle like pattern. | ||
**Jigsaw-puzzle pieces each ~ 100-500 micrometres in size (largest dimension). | **Jigsaw-puzzle pieces each ~ 100-500 micrometres in size (largest dimension). | ||
Line 76: | Line 78: | ||
===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Paget_disease_of_bone_-_high_mag.jpg | Paget disease - bone - high mag. (WC/Nephron) | Image:Paget_disease_of_bone_-_intermed_mag.jpg | Paget's disease - bone - intermed. mag. (WC/Nephron) | ||
Image:Paget_disease_of_bone_- | Image:Paget_disease_of_bone_-_high_mag.jpg | Paget's disease - bone - high mag. (WC/Nephron) | ||
Image:Paget_disease_of_bone_-_very_high_mag.jpg | Paget's disease - bone - very high mag. (WC/Nephron) | |||
Image:Bone PagetDisease MP2 PA (2).JPG|Early Paget disease - cellular fibro-osseous lesion osteoclastic resorptive lacunae.(SKB) | |||
Image:Bone PagetDisease MP2 PA.JPG|Early Paget disease - Cellular fibro-osseous lesions with less calcified osteoid trabeculae exhibiting some osteoblastic rimming. (SKB) | |||
</gallery> | </gallery> | ||
edits