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Difference between revisions of "Paget's disease of the bone"
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Paget's disease of the bone (view source)
Revision as of 07:30, 27 December 2014
, 07:30, 27 December 2014→Microscopic
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Paget_disease_of_bone_-_high_mag.jpg | |||
| Width = | |||
| Caption = Paget's disease of the bone. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = bone matrix has jigsaw-puzzle like pattern (jigsaw-puzzle pieces each ~ 100-500 micrometres in size in largest dimension), increased osteoclast activity | |||
| Subtypes = | |||
| LMDDx = | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[bone]] | |||
| Assdx = [[fracture of bone]], [[secondary osteosarcoma]] | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = +/-deafness | |||
| Symptoms = +/-bone pain | |||
| Prevalence = | |||
| Bloodwork = elevated ALP | |||
| Rads = bony deformity, "sunburst" skull | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Paget's disease of the bone''' is an uncommon benign disorder of [[bone]] with distinctive radiographic findings. | '''Paget's disease of the bone''' is an uncommon benign disorder of [[bone]] with distinctive radiographic findings. | ||
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==Microscopic== | ==Microscopic== | ||
Features:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref> | Features:<ref name=emed_paget>URL: [http://emedicine.medscape.com/article/311688-overview http://emedicine.medscape.com/article/311688-overview]. Accessed on: 25 December 2010.</ref> | ||
*Lytic and mixed Paget disease are cellular and fibro-osseous (bone and fibrous components) | |||
*Sclerotic Paget disease has thickened bone trabeculae. | |||
*Bone matrix has jigsaw-puzzle like pattern. | *Bone matrix has jigsaw-puzzle like pattern. | ||
**Jigsaw-puzzle pieces each ~ 100-500 micrometres in size (largest dimension). | **Jigsaw-puzzle pieces each ~ 100-500 micrometres in size (largest dimension). | ||
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===Images=== | ===Images=== | ||
<gallery> | <gallery> | ||
Image:Paget_disease_of_bone_-_high_mag.jpg | Paget disease - bone - high mag. (WC/Nephron) | Image:Paget_disease_of_bone_-_intermed_mag.jpg | Paget's disease - bone - intermed. mag. (WC/Nephron) | ||
Image:Paget_disease_of_bone_- | Image:Paget_disease_of_bone_-_high_mag.jpg | Paget's disease - bone - high mag. (WC/Nephron) | ||
Image:Paget_disease_of_bone_-_very_high_mag.jpg | Paget's disease - bone - very high mag. (WC/Nephron) | |||
Image:Bone PagetDisease MP2 PA (2).JPG|Early Paget disease - cellular fibro-osseous lesion osteoclastic resorptive lacunae.(SKB) | |||
Image:Bone PagetDisease MP2 PA.JPG|Early Paget disease - Cellular fibro-osseous lesions with less calcified osteoid trabeculae exhibiting some osteoblastic rimming. (SKB) | |||
</gallery> | </gallery> | ||