Difference between revisions of "PEComa"

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(+EM)
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**Actin.<ref name=pmid18080139/>
**Actin.<ref name=pmid18080139/>
**Myosin.
**Myosin.
==EM==
*Premelanosomes.<ref name=pmid14629307>{{Cite journal  | last1 = Park | first1 = SH. | last2 = Ro | first2 = JY. | last3 = Kim | first3 = HS. | last4 = Lee | first4 = ES. | title = Perivascular epithelioid cell tumor of the uterus: immunohistochemical, ultrastructural and molecular study. | journal = Pathol Int | volume = 53 | issue = 11 | pages = 800-5 | month = Nov | year = 2003 | doi =  | PMID = 14629307 }}</ref>


==See also==
==See also==

Revision as of 01:06, 1 June 2012

PEComa is a family of tumours derived from perivascular epithelioid cells (PECs).

General

The PEComa family

Microscopic

Features:[1]

  • Epithelioid morphology.
  • Clear or granular cytoplasm.
  • Central oval (or round) nucleus.
    • Indistinct/small nucleolus.

DDx:

Images:

IHC

  • Melanocytic markers
    • HMB-45.[1]
    • Melan A (Mart 1).
    • Mitf.
  • Myogenic markers
    • Calponin.
    • Actin.[1]
    • Myosin.

EM

  • Premelanosomes.[3]

See also

References

  1. 1.0 1.1 1.2 1.3 Martignoni G, Pea M, Reghellin D, Zamboni G, Bonetti F (February 2008). "PEComas: the past, the present and the future". Virchows Arch. 452 (2): 119–32. doi:10.1007/s00428-007-0509-1. PMC 2234444. PMID 18080139. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234444/.
  2. Bonetti, F.; Martignoni, G.; Colato, C.; Manfrin, E.; Gambacorta, M.; Faleri, M.; Bacchi, C.; Sin, VC. et al. (Jun 2001). "Abdominopelvic sarcoma of perivascular epithelioid cells. Report of four cases in young women, one with tuberous sclerosis.". Mod Pathol 14 (6): 563-8. doi:10.1038/modpathol.3880351. PMID 11406657.
  3. Park, SH.; Ro, JY.; Kim, HS.; Lee, ES. (Nov 2003). "Perivascular epithelioid cell tumor of the uterus: immunohistochemical, ultrastructural and molecular study.". Pathol Int 53 (11): 800-5. PMID 14629307.