Difference between revisions of "Ovarian tumours"

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Ovarian tumours (view source)

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→‎Serous carcinoma of the ovary
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==Serous carcinoma of the ovary==
==Serous carcinoma of the ovary==
*[[AKA]] ''ovarian [[serous carcinoma]]''.
*[[AKA]] ''ovarian [[serous carcinoma]]''.
 
{{Serous carcinoma of the ovary}}
===General===
*Most common malignant ovarian tumour in the eldery.
*Poor prognosis.
 
===Microscopic===
Features:
*Marked nuclear pleomorphism:
**Variation in size - usually marked.
**Variation in staining.
**Variation in shape.
*Prominent nucleolus - '''key feature'''.
*Eccentric nucleus.
*Architecture:
**Solid.
**Papillary - classic.
**Glandular - uncommon.
*+/-Psammoma bodies - uncommon.
*+/-Necrosis - often extensive.
 
DDx:
*[[Clear cell carcinoma of the ovary]] - less nuclear size variation.
*[[Endometrioid carcinoma of the ovary]] - usu. lower grade.
*[[Primary peritoneal serous carcinoma]] - bulk of tumour in peritoneum, small ovarian tumour.
*Other non-ovarian serous carcinomas - ''see [[serous carcinoma]]''.
*[[Ovarian serous borderline tumour]] - mild to moderate nuclear atypia, no invasion, few mitoses.
 
====Images====
<gallery>
Image:Serous_carcinoma_cytology.jpg | Serous carcinoma - cytology. (WC)
</gallery>
===IHC===
*WT-1 +ve - '''key immunostain'''.<ref name=pmid18830127>{{Cite journal  | last1 = Köbel | first1 = M. | last2 = Kalloger | first2 = SE. | last3 = Carrick | first3 = J. | last4 = Huntsman | first4 = D. | last5 = Asad | first5 = H. | last6 = Oliva | first6 = E. | last7 = Ewanowich | first7 = CA. | last8 = Soslow | first8 = RA. | last9 = Gilks | first9 = CB. | title = A limited panel of immunomarkers can reliably distinguish between clear cell and high-grade serous carcinoma of the ovary. | journal = Am J Surg Pathol | volume = 33 | issue = 1 | pages = 14-21 | month = Jan | year = 2009 | doi = 10.1097/PAS.0b013e3181788546 | PMID = 18830127 }}</ref>
*CK7 +ve.
*CA-125 +ve.
*ER +ve.<ref name=pmid21164285>{{Cite journal  | last1 = DeLair | first1 = D. | last2 = Oliva | first2 = E. | last3 = Köbel | first3 = M. | last4 = Macias | first4 = A. | last5 = Gilks | first5 = CB. | last6 = Soslow | first6 = RA. | title = Morphologic spectrum of immunohistochemically characterized clear cell carcinoma of the ovary: a study of 155 cases. | journal = Am J Surg Pathol | volume = 35 | issue = 1 | pages = 36-44 | month = Jan | year = 2011 | doi = 10.1097/PAS.0b013e3181ff400e | PMID = 21164285 }}</ref>
*p53 +ve.
 
Others:
*HNF-1beta -ve.<ref>{{Cite journal  | last1 = Tsuchiya | first1 = A. | last2 = Sakamoto | first2 = M. | last3 = Yasuda | first3 = J. | last4 = Chuma | first4 = M. | last5 = Ohta | first5 = T. | last6 = Ohki | first6 = M. | last7 = Yasugi | first7 = T. | last8 = Taketani | first8 = Y. | last9 = Hirohashi | first9 = S. | title = Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. | journal = Am J Pathol | volume = 163 | issue = 6 | pages = 2503-12 | month = Dec | year = 2003 | doi =  | PMID = 14633622 | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892387/?tool=pubmed }}</ref><ref name=omim189907>{{OMIM|189907}}</ref>
**Usually +ve in [[clear cell carcinoma of the ovary]].


==Serous cystadenoma of the ovary==
==Serous cystadenoma of the ovary==
Michael
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