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Difference between revisions of "Ovarian tumours"
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→Granulosa cell tumour: more
(→Granulosa cell tumour: more) |
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*[http://www.pathology.cn/bbs/forum.php?mod=viewthread&tid=57445 Possible SCTAT (pathology.cn)]. | *[http://www.pathology.cn/bbs/forum.php?mod=viewthread&tid=57445 Possible SCTAT (pathology.cn)]. | ||
== | ==Juvenile granulosa cell tumour== | ||
===General=== | ===General=== | ||
*May secrete estrogen. | *May secrete estrogen. | ||
**May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]]. | **May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]]. | ||
===Gross=== | ===Gross=== | ||
* | *Classically solid. | ||
* | |||
===Microscopic=== | |||
Features: | |||
*Microcystic spaces. | |||
*Moderate-to-marked nuclear atypia. | |||
*Cuboidal-to-polygonal cell in sheets or stands or cords. | |||
*Basophilic cytoplasm. | |||
Notes: | |||
*Juvenile variant of GCT has more nuclear pleomorphism. | |||
Images: | |||
*[[WC]]: | |||
**[http://commons.wikimedia.org/wiki/File:Juvenile_granulosa_cell_tumour_-_intermed_mag.jpg Juvenile granulosa cell tumour - intermed. mag. (WC)]. | |||
**[http://commons.wikimedia.org/wiki/File:Juvenile_granulosa_cell_tumour_-_very_high_mag.jpg Juvenile granulosa cell tumour - very high mag. (WC)]. | |||
===IHC=== | |||
* Inhibin positive.<ref name=Ref_PBoD1102>{{Ref PBoD|1102}}</ref> | |||
** Inhibin negative in ''[[Brenner tumour]]''. | |||
*Calretinin +ve. | |||
==Adult granulosa cell tumour== | |||
*[[AKA]] ''granulosa cell tumour''. | |||
**Should not be confused with ''[[juvenile granulosa cell tumour]]''. | |||
===General=== | |||
*May secrete estrogen. | |||
**May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]]. | |||
===Gross=== | |||
*Classically solid. | |||
===Microscopic=== | ===Microscopic=== | ||
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Note: | Note: | ||
*There is a "10% rule" -- if less than 10% of a SCST is granulosa cells... it isn't granulosa cell tumour. | *There is a "10% rule" -- if less than 10% of a SCST is granulosa cells... it isn't granulosa cell tumour. | ||
*Juvenile variant of GCT has more nuclear pleomorphism. | |||
DDx: | DDx: | ||
| Line 504: | Line 533: | ||
* [[Brenner tumour]]. | * [[Brenner tumour]]. | ||
* [[Sertoli cell tumour]]. | * [[Sertoli cell tumour]]. | ||
===IHC=== | ===IHC=== | ||