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===General=== | ===General=== | ||
*Sertoli and leydig cells are normal in the [[testis]]. | *Sertoli and leydig cells are normal in the [[testis]]. | ||
*Poorly differentiated tumours have sarcomatous features.<ref name=Ref_PBoD1103>{{Ref PBoD|1103}}</ref> | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=Ref_PBoD1103>{{Ref PBoD|1103}}</ref> | Features: | ||
* | # Sertoli ''or'' Leydig cells.<ref name=Ref_PBoD1103>{{Ref PBoD|1103}}</ref> | ||
* +/- Sarcomatous features (mucinous glands, bone, cartilage). | #* Leydig cells: | ||
#** Abundant solid eosinophilic cytoplasm. | |||
#** Round nuclei with fine chromatin and a small or indistinct [[nucleolus]]. | |||
#** Often in small clusters ~ 5-25 cells/cluster. | |||
#* Sertoli cells: | |||
#** Pale/clear vacuolated cytoplasm. | |||
#** Irregular nuclei with irregular/vacuolated-appearing chromatin. | |||
#** Architecture: tubules, cords or sheets. | |||
# Stroma. | |||
# +/- Sarcomatous features (mucinous glands, bone, cartilage). | |||
Images: | |||
*[http://commons.wikimedia.org/wiki/File:Sertoli-Leydig_cell_tumour_-_intermed_mag.jpg Sertoli-Leydig cell tumour - intermed. mag. (WC)]. | |||
*[http://commons.wikimedia.org/wiki/File:Sertoli-Leydig_cell_tumour_-_very_high_mag.jpg Sertoli-Leydig cell tumour - very high mag. (WC)]. | |||
==Pure Leydig cell tumour== | ==Pure Leydig cell tumour== |
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