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Difference between revisions of "Ovarian tumours"
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→Granulosa component: tweak
m (→Brenner tumour: +TCC of ovary) |
(→Granulosa component: tweak) |
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| Line 412: | Line 412: | ||
NEED TO FIX. | NEED TO FIX. | ||
==Granulosa | ==Granulosa cell tumour== | ||
===General=== | ===General=== | ||
*''Adult'' and ''juvenile'' variants. | *''Adult'' and ''juvenile'' variants. | ||
**Juvenile variant - more nuclear pleomorphism. | **Juvenile variant - more nuclear pleomorphism. | ||
* | *May secrete estrogen. | ||
**May present with endometrial pathology, e.g. [[endometrial hyperplasia]] or [[endometrial carcinoma]]. | **May present with endometrial pathology, e.g. [[endometrial hyperplasia]] ''or'' endometrioid [[endometrial carcinoma]]. | ||
===Gross=== | ===Gross=== | ||
*Solid. | *Solid. | ||
*May be cystic. (???) | |||
=== | ===Microscopic=== | ||
Features: | |||
* Classic appearance includes gland-like structures filled with acidophilic material (Call-Exner bodies). | * Classic appearance includes gland-like structures filled with acidophilic material (Call-Exner bodies). | ||
* Small cuboidal to polygonal cell in sheets or stands or cords. | * Small cuboidal to polygonal cell in sheets or stands or cords. | ||
DDx: | |||
* [[Urothelial cell carcinoma]] (UCC). | |||
** UCC usually has extensive necrosis. | |||
* [[Brenner tumour]] (???). | |||
===IHC=== | ===IHC=== | ||
* Inhibin positive.<ref name=Ref_PBoD1102>{{Ref PBoD|1102}}</ref> | * Inhibin positive.<ref name=Ref_PBoD1102>{{Ref PBoD|1102}}</ref> | ||
** Inhibin negative in ''[[Brenner tumour]]''. | ** Inhibin negative in ''[[Brenner tumour]]''. | ||
==Fibroma-thecoma group== | ==Fibroma-thecoma group== | ||