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Difference between revisions of "Ovarian tumours"
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→Clear cell carcinoma of the ovary: more
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Features: | Features: | ||
*Cystic/tubular architecture - important low power feature. | *Cystic/tubular architecture - important low power feature. | ||
*Clear cells - cytoplasm is clear - '''key feature'''. | **May be papillary and/or solid. | ||
*Clear cells - cytoplasm is clear - '''key feature'''. † | |||
*[[Hobnail morphology]] - apical surface larger than basal surface. | *[[Hobnail morphology]] - apical surface larger than basal surface. | ||
**"Nuclei bulge into the lumen". | **"Nuclei bulge into the lumen". | ||
*Hyaline droplets -- common, as in ''[[clear cell renal cell carcinoma]]''. | *Hyaline droplets -- common, as in ''[[clear cell renal cell carcinoma]]''. | ||
**Eosinophilic bodies within lumen. | **Eosinophilic bodies within lumen. | ||
**Seen in approximately 1/4 of cases.<ref name=pmid22885379/> | |||
*Nucleoli - prominent. | *Nucleoli - prominent. | ||
Note: | Note: | ||
*Clear cell adenocarcinoma does not have to have clear cells. Yes, this is stupid; it is like ''[[papillary thyroid carcinoma]]'' -- which often isn't papillary -- see ''[[no truth in names]]''. | *† Clear cell adenocarcinoma does not have to have clear cells. Yes, this is stupid; it is like ''[[papillary thyroid carcinoma]]'' -- which often isn't papillary -- see ''[[no truth in names]]''. | ||
**The ''hobnail morphology'' is important if this is the case. | **The ''hobnail morphology'' is important if this is the case. | ||
DDx: | DDx: | ||
*[[Serous carcinoma of the ovary]]. | *[[Serous carcinoma of the ovary]] - have larger papillae,<ref name=pmid22885379/> more group pleomorphism. | ||
*High-grade [[endometrioid carcinoma of the ovary]]. | *High-grade [[endometrioid carcinoma of the ovary]]. | ||
*[[Metastasis|Metatstatic]] [[clear cell carcinoma]]. | *[[Metastasis|Metatstatic]] [[clear cell carcinoma]]. | ||
*Borderline clear cell lesion of the ovary - very rare; an under sampled carcinoma considered more probable.<ref name=pmid22885379/> | *Borderline clear cell lesion of the ovary - very rare; an under sampled carcinoma considered more probable.<ref name=pmid22885379/> | ||
*[[Arias-Stella reaction]] within [[endometriosis]]. | |||
Images: | Images: | ||