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'''Osteoid osteoma''', abbreviated '''OO''', is benign primary [[bone tumour]]. | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Osteoid osteoma - low mag.jpg | |||
| Width = | |||
| Caption = Osteoid osteoma. [[H&E stain]]. | |||
| Micro = anastomosing bony [[trabeculae]] with variable mineralization, osteoblast rimming, no nuclear atypia of osteocytes | |||
| Subtypes = | |||
| LMDDx = [[osteoblastoma]], [[osteosarcoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[bone]] (femur > tibia > spine > elsewhere) | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = pain relieved by [[NSAIDs]] | |||
| Signs = | |||
| Symptoms = extremely painful | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = <= 2.0 cm (larger lesions ''[[osteoblastoma]]'') | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = [[osteosarcoma]] | |||
}} | |||
'''Osteoid osteoma''', abbreviated '''OO''', is benign primary [[bone tumour]]. It is grouped with the [[chondro-osseous tumours]]. | |||
It should '''not''' be confused with an ''[[osteoma]]''. | |||
==General== | ==General== | ||
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*Bone: femur > tibia > spine > elsewhere.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref><ref name=radiologyassistant>URL: [http://www.radiologyassistant.nl/en/494e15cbf0d8d http://www.radiologyassistant.nl/en/494e15cbf0d8d]. Accessed on: 7 May 2012.</ref> | *Bone: femur > tibia > spine > elsewhere.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref><ref name=radiologyassistant>URL: [http://www.radiologyassistant.nl/en/494e15cbf0d8d http://www.radiologyassistant.nl/en/494e15cbf0d8d]. Accessed on: 7 May 2012.</ref> | ||
*Most common location (in bone): diaphysis.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref> | *Most common location (in bone): diaphysis.<ref name=uthscsa>URL: http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html http://radiology.uthscsa.edu/CME/ELTXT/OOT/skeletallocation.html]. Accessed on: 7 May 2012.</ref> | ||
*'''Must''' be less than 2 cm - as per WHO definition.<ref name=pmid25224389>{{Cite journal | last1 = Yalcinkaya | first1 = U. | last2 = Doganavsargil | first2 = B. | last3 = Sezak | first3 = M. | last4 = Kececi | first4 = B. | last5 = Argin | first5 = M. | last6 = Basdemir | first6 = G. | last7 = Oztop | first7 = F. | title = Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. | journal = Ann Diagn Pathol | volume = 18 | issue = 6 | pages = 319-25 | month = Dec | year = 2014 | doi = 10.1016/j.anndiagpath.2014.08.006 | PMID = 25224389 }}</ref> ‡ | |||
**Larger lesions with the same microscopy are ''[[osteoblastoma]]s''. | |||
*Central nidus with surround sclerotic bone.<ref name=pmid24093694>{{Cite journal | last1 = Boscainos | first1 = PJ. | last2 = Cousins | first2 = GR. | last3 = Kulshreshtha | first3 = R. | last4 = Oliver | first4 = TB. | last5 = Papagelopoulos | first5 = PJ. | title = Osteoid osteoma. | journal = Orthopedics | volume = 36 | issue = 10 | pages = 792-800 | month = Oct | year = 2013 | doi = 10.3928/01477447-20130920-10 | PMID = 24093694 }}</ref> | |||
Note: | |||
*‡ Previously, the [[diagnostic size cutoffs|diagnostic size cutoff]] was <=1.5 cm.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | |||
Images: | Images: | ||
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**Variable mineralization. | **Variable mineralization. | ||
***Mineralization (calcium '''p'''hosphate) = '''p'''urple on [[H&E stain]]. | ***Mineralization (calcium '''p'''hosphate) = '''p'''urple on [[H&E stain]]. | ||
** | **Osteoblast rimming. | ||
***Cells line-up at edge of bone. | ***Cells line-up at edge of bone. | ||
Note: | Note: | ||
*Histomorphologically near identical/indistinguishable from ''[[osteoblastoma]]'';<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> one needs some history to make the diagnosis. | *Histomorphologically near identical/indistinguishable from ''[[osteoblastoma]]'';<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> one needs some history to make the diagnosis. | ||
DDx: | |||
*[[Osteosarcoma]] - lace-like osteoid, no nidus. | |||
*[[Osteoblastoma]] - larger lesion, clinical features different. | |||
===Images=== | ===Images=== |
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