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Difference between revisions of "Osteoblastoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Osteoblastoma_-_low_mag.jpg | |||
| Width = | |||
| Caption = Osteoblastoma. [[H&E stain]]. | |||
| Micro = anastomosing bony [[trabeculae]] with variable mineralization, osteoblastic rimming, no nuclear atypia of osteocytes | |||
| Subtypes = | |||
| LMDDx = [[osteoid osteoma]], [[osteosarcoma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[bone]] - vertebral column typically, other bones | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = usu. 15-20 years old, males > females | |||
| Signs = | |||
| Symptoms = usu. pain | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = often >=2.0 cm (similar lesions 1-2 cm may be [[osteoid osteoma]]), often well-circumscribed, +/-cortical expansion, +/-cortical destruction | |||
| Endoscopy = | |||
| Prognosis = benign, may be locally destructive | |||
| Other = | |||
| ClinDDx = [[osteosarcoma]] | |||
}} | |||
'''Osteoblastoma''' is benign primary [[bone tumour]]. It is grouped with the [[chondro-osseous tumours]]. | |||
==General== | |||
*Benign bone tumour - that can be locally destructive and occasionally recurs.<ref name=pmid8119712/> | |||
*Uncommon.<ref name=pmid23362588>{{Cite journal | last1 = Khan | first1 = IS. | last2 = Thakur | first2 = JD. | last3 = Chittiboina | first3 = P. | last4 = Nanda | first4 = A. | title = Large sacral osteoblastoma: a case report and review of multi-disciplinary management strategies. | journal = J La State Med Soc | volume = 164 | issue = 5 | pages = 251-5 | month = | year = | doi = | PMID = 23362588 }}</ref> | |||
*Typically age 15-20 and male (male:female = ~2:1).<ref name=pmid20345366>{{Cite journal | last1 = Villalobos | first1 = CE. | last2 = Rybak | first2 = LD. | last3 = Steiner | first3 = GC. | last4 = Wittig | first4 = JC. | title = Osteoblastoma of the sternum--case report and review of the literature. | journal = Bull NYU Hosp Jt Dis | volume = 68 | issue = 1 | pages = 55-9 | month = | year = 2010 | doi = | PMID = 20345366 }}</ref> | |||
**Very large age range.<ref name=pmid8119712/> | |||
*Treatment: resection.<ref name=pmid20345366/> | |||
==Gross== | |||
*Bone. | |||
**Vertebral column and sacrum - most common in one large series.<ref name=pmid8119712>{{Cite journal | last1 = Lucas | first1 = DR. | last2 = Unni | first2 = KK. | last3 = McLeod | first3 = RA. | last4 = O'Connor | first4 = MI. | last5 = Sim | first5 = FH. | title = Osteoblastoma: clinicopathologic study of 306 cases. | journal = Hum Pathol | volume = 25 | issue = 2 | pages = 117-34 | month = Feb | year = 1994 | doi = | PMID = 8119712 }}</ref> | |||
*Size important as per WHO definition:<ref name=pmid25224389>{{Cite journal | last1 = Yalcinkaya | first1 = U. | last2 = Doganavsargil | first2 = B. | last3 = Sezak | first3 = M. | last4 = Kececi | first4 = B. | last5 = Argin | first5 = M. | last6 = Basdemir | first6 = G. | last7 = Oztop | first7 = F. | title = Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. | journal = Ann Diagn Pathol | volume = 18 | issue = 6 | pages = 319-25 | month = Dec | year = 2014 | doi = 10.1016/j.anndiagpath.2014.08.006 | PMID = 25224389 }}</ref> ‡ | |||
**>= 2.0 cm: osteoblastoma. | |||
**<=1.0 cm: [[osteoid osteoma]]. | |||
**>1 cm and <2 cm: clinical and radiologic criteria should be considered. | |||
Note: | |||
*‡1.5 cm is a [[diagnostic size cutoff]] seen in older references.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | |||
===Radiology=== | |||
Features: | |||
*Often well-circumscribed, +/-cortical expansion, +/-cortical destruction.<ref name=pmid8119712/> | |||
Note: | |||
*May be described as malignant by radiology.<ref name=pmid8119712/> | |||
==Microscopic== | |||
Features:<ref name=Ref_Sternberg4_285>{{Ref Sternberg4|285}}</ref> | |||
*Anastomosing bony [[trabeculae]] with: | |||
**Osteoblastic rimming. | |||
***Cells line-up at edge of bone. | |||
Notes: | |||
*Histomorphologically near identical/indistinguishable from ''[[osteoid osteoma]]''.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | |||
DDx: | |||
*[[Osteosarcoma]].<ref name=pmid8119712/> | |||
===Images=== | |||
<gallery> | |||
Image:Osteoblastoma_-_high_mag.jpg | Osteoblastoma - high mag. (WC) | |||
Image:Osteoblastoma_-_low_mag.jpg | Osteoblastoma - low mag. (WC) | |||
Image:Bone Osteoblastoma LP PA.JPG|Osteoblastoma - low power. (SKB) | |||
Image:Bone Osteoblastoma MP3 PA.JPG|Osteoblastoma - medium power. (SKB) | |||
Image:Bone Osteoblastoma MP2 PA.JPG|Osteoblastoma - medium power. (SKB) | |||
Image:Bone Osteoblastoma OsteoblasticRimming PA.JPG|Osteoblastoma - Higher power - Osteoblastic rimming. (SKB) | |||
</gallery> | |||
==Sign out== | |||
<pre> | |||
BONE, LEFT FEMUR, EXCISION: | |||
- OSTEOBLASTOMA. | |||
</pre> | |||
==See also== | |||
*[[Chondro-osseous tumours]]. | |||
*[[Bone]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Chondro-osseous tumours]] | |||
[[Category:Diagnosis]] | |||