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Difference between revisions of "Osteoblastoma"
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| Width = | | Width = | ||
| Caption = Osteoblastoma. [[H&E stain]]. | | Caption = Osteoblastoma. [[H&E stain]]. | ||
| Micro = anastomosing bony [[trabeculae]] with variable mineralization, | | Micro = anastomosing bony [[trabeculae]] with variable mineralization, osteoblastic rimming, no nuclear atypia of osteocytes | ||
| Subtypes = | | Subtypes = | ||
| LMDDx = [[osteoid osteoma]], [[osteosarcoma]] | | LMDDx = [[osteoid osteoma]], [[osteosarcoma]] | ||
| Line 22: | Line 22: | ||
| Prevalence = | | Prevalence = | ||
| Bloodwork = | | Bloodwork = | ||
| Rads = > | | Rads = often >=2.0 cm (similar lesions 1-2 cm may be [[osteoid osteoma]]), often well-circumscribed, +/-cortical expansion, +/-cortical destruction | ||
| Endoscopy = | | Endoscopy = | ||
| Prognosis = benign, may be locally destructive | | Prognosis = benign, may be locally destructive | ||
| Line 28: | Line 28: | ||
| ClinDDx = [[osteosarcoma]] | | ClinDDx = [[osteosarcoma]] | ||
}} | }} | ||
'''Osteoblastoma''' is benign primary [[bone tumour]]. | '''Osteoblastoma''' is benign primary [[bone tumour]]. It is grouped with the [[chondro-osseous tumours]]. | ||
==General== | ==General== | ||
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*Uncommon.<ref name=pmid23362588>{{Cite journal | last1 = Khan | first1 = IS. | last2 = Thakur | first2 = JD. | last3 = Chittiboina | first3 = P. | last4 = Nanda | first4 = A. | title = Large sacral osteoblastoma: a case report and review of multi-disciplinary management strategies. | journal = J La State Med Soc | volume = 164 | issue = 5 | pages = 251-5 | month = | year = | doi = | PMID = 23362588 }}</ref> | *Uncommon.<ref name=pmid23362588>{{Cite journal | last1 = Khan | first1 = IS. | last2 = Thakur | first2 = JD. | last3 = Chittiboina | first3 = P. | last4 = Nanda | first4 = A. | title = Large sacral osteoblastoma: a case report and review of multi-disciplinary management strategies. | journal = J La State Med Soc | volume = 164 | issue = 5 | pages = 251-5 | month = | year = | doi = | PMID = 23362588 }}</ref> | ||
*Typically age 15-20 and male (male:female = ~2:1).<ref name=pmid20345366>{{Cite journal | last1 = Villalobos | first1 = CE. | last2 = Rybak | first2 = LD. | last3 = Steiner | first3 = GC. | last4 = Wittig | first4 = JC. | title = Osteoblastoma of the sternum--case report and review of the literature. | journal = Bull NYU Hosp Jt Dis | volume = 68 | issue = 1 | pages = 55-9 | month = | year = 2010 | doi = | PMID = 20345366 }}</ref> | *Typically age 15-20 and male (male:female = ~2:1).<ref name=pmid20345366>{{Cite journal | last1 = Villalobos | first1 = CE. | last2 = Rybak | first2 = LD. | last3 = Steiner | first3 = GC. | last4 = Wittig | first4 = JC. | title = Osteoblastoma of the sternum--case report and review of the literature. | journal = Bull NYU Hosp Jt Dis | volume = 68 | issue = 1 | pages = 55-9 | month = | year = 2010 | doi = | PMID = 20345366 }}</ref> | ||
**Very large age range.<ref name=pmid8119712/> | |||
*Treatment: resection.<ref name=pmid20345366/> | *Treatment: resection.<ref name=pmid20345366/> | ||
| Line 39: | Line 40: | ||
*Bone. | *Bone. | ||
**Vertebral column and sacrum - most common in one large series.<ref name=pmid8119712>{{Cite journal | last1 = Lucas | first1 = DR. | last2 = Unni | first2 = KK. | last3 = McLeod | first3 = RA. | last4 = O'Connor | first4 = MI. | last5 = Sim | first5 = FH. | title = Osteoblastoma: clinicopathologic study of 306 cases. | journal = Hum Pathol | volume = 25 | issue = 2 | pages = 117-34 | month = Feb | year = 1994 | doi = | PMID = 8119712 }}</ref> | **Vertebral column and sacrum - most common in one large series.<ref name=pmid8119712>{{Cite journal | last1 = Lucas | first1 = DR. | last2 = Unni | first2 = KK. | last3 = McLeod | first3 = RA. | last4 = O'Connor | first4 = MI. | last5 = Sim | first5 = FH. | title = Osteoblastoma: clinicopathologic study of 306 cases. | journal = Hum Pathol | volume = 25 | issue = 2 | pages = 117-34 | month = Feb | year = 1994 | doi = | PMID = 8119712 }}</ref> | ||
* | *Size important as per WHO definition:<ref name=pmid25224389>{{Cite journal | last1 = Yalcinkaya | first1 = U. | last2 = Doganavsargil | first2 = B. | last3 = Sezak | first3 = M. | last4 = Kececi | first4 = B. | last5 = Argin | first5 = M. | last6 = Basdemir | first6 = G. | last7 = Oztop | first7 = F. | title = Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients. | journal = Ann Diagn Pathol | volume = 18 | issue = 6 | pages = 319-25 | month = Dec | year = 2014 | doi = 10.1016/j.anndiagpath.2014.08.006 | PMID = 25224389 }}</ref> ‡ | ||
**>= 2.0 cm: osteoblastoma. | |||
**<=1.0 cm: [[osteoid osteoma]]. | |||
**>1 cm and <2 cm: clinical and radiologic criteria should be considered. | |||
Note: | |||
*‡1.5 cm is a [[diagnostic size cutoff]] seen in older references.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | |||
===Radiology=== | ===Radiology=== | ||
| Line 51: | Line 58: | ||
Features:<ref name=Ref_Sternberg4_285>{{Ref Sternberg4|285}}</ref> | Features:<ref name=Ref_Sternberg4_285>{{Ref Sternberg4|285}}</ref> | ||
*Anastomosing bony [[trabeculae]] with: | *Anastomosing bony [[trabeculae]] with: | ||
** | **Osteoblastic rimming. | ||
***Cells line-up at edge of bone. | ***Cells line-up at edge of bone. | ||
| Line 64: | Line 71: | ||
Image:Osteoblastoma_-_high_mag.jpg | Osteoblastoma - high mag. (WC) | Image:Osteoblastoma_-_high_mag.jpg | Osteoblastoma - high mag. (WC) | ||
Image:Osteoblastoma_-_low_mag.jpg | Osteoblastoma - low mag. (WC) | Image:Osteoblastoma_-_low_mag.jpg | Osteoblastoma - low mag. (WC) | ||
Image:Bone Osteoblastoma LP PA.JPG|Osteoblastoma - low power. (SKB) | |||
Image:Bone Osteoblastoma MP3 PA.JPG|Osteoblastoma - medium power. (SKB) | |||
Image:Bone Osteoblastoma MP2 PA.JPG|Osteoblastoma - medium power. (SKB) | |||
Image:Bone Osteoblastoma OsteoblasticRimming PA.JPG|Osteoblastoma - Higher power - Osteoblastic rimming. (SKB) | |||
</gallery> | </gallery> | ||