Difference between revisions of "Oligoastrocytoma"

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WHO 2016
m (wikify)
(WHO 2016)
 
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'''Oligoastrocytoma''' is an uncommon [[neuropathology tumour]] that is suspected '''not''' to be a distinct entity.<ref name=pmid25143301>{{Cite journal  | last1 = Sahm | first1 = F. | last2 = Reuss | first2 = D. | last3 = Koelsche | first3 = C. | last4 = Capper | first4 = D. | last5 = Schittenhelm | first5 = J. | last6 = Heim | first6 = S. | last7 = Jones | first7 = DT. | last8 = Pfister | first8 = SM. | last9 = Herold-Mende | first9 = C. | title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. | journal = Acta Neuropathol | volume = 128 | issue = 4 | pages = 551-9 | month = Oct | year = 2014 | doi = 10.1007/s00401-014-1326-7 | PMID = 25143301 }}</ref>
'''Oligoastrocytoma, NOS''' is an uncommon [[neuropathology tumour]] that is '''no longer''' a distinct entity.<ref name=pmid25143301>{{Cite journal  | last1 = Sahm | first1 = F. | last2 = Reuss | first2 = D. | last3 = Koelsche | first3 = C. | last4 = Capper | first4 = D. | last5 = Schittenhelm | first5 = J. | last6 = Heim | first6 = S. | last7 = Jones | first7 = DT. | last8 = Pfister | first8 = SM. | last9 = Herold-Mende | first9 = C. | title = Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma. | journal = Acta Neuropathol | volume = 128 | issue = 4 | pages = 551-9 | month = Oct | year = 2014 | doi = 10.1007/s00401-014-1326-7 | PMID = 25143301 }}</ref>


==General==
==General==
*Mixed tumour by definition.
*Mixed tumour by definition.
*More sophisticated testing usually allows separation into ''oligodendroglioma'' or ''astrocytoma''.<ref name=pmid25143301/>  
*After [[IDH-1]]/2 mutation screening and LOH 1p/19q analysis almost all tumors are either classified as ''oligodendroglioma'' or ''astrocytoma''.<ref name=pmid25143301/>  
*The NOS category is reserved for cases without genetic testing.<ref>{{Cite journal  | last1 = Louis | first1 = DN. | last2 = Perry | first2 = A. | last3 = Reifenberger | first3 = G. | last4 = von Deimling | first4 = A. | last5 = Figarella-Branger | first5 = D. | last6 = Cavenee | first6 = WK. | last7 = Ohgaki | first7 = H. | last8 = Wiestler | first8 = OD. | last9 = Kleihues | first9 = P. | title = The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. | journal = Acta Neuropathol | volume = 131 | issue = 6 | pages = 803-20 | month = Jun | year = 2016 | doi = 10.1007/s00401-016-1545-1 | PMID = 27157931 }}</ref>
 
Two types exist:
*Oligoastrocytoma, NOS (Grade II WHO; ICD-O: 9382/3)
*Anaplastic Oligoastrocytoma, NOS (Grade III WHO; ICD-O: 9382/3)
 


==Microscopic==
==Microscopic==
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*[[Anaplastic astrocytoma]].
*[[Anaplastic astrocytoma]].
*[[Oligodendroglioma]].
*[[Oligodendroglioma]].
*[[Diffuse astrocytoma]].
*[[Anaplastic oligodendroglioma]]
*[[Glioblastoma]]


===IHC===
===IHC===
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Others:
Others:
*Ki-67 ~10%. (???)
*Ki-67 3-10%.
*p53 - focally +ve. (???)
*ATRX loss (in cases without LOH1p/19q).
*[[IDH-1]] +ve. (85%)
*[[IDH-1]] +ve. (85%).


==See also==
==See also==
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[[Category:Neuropathology tumours]]
[[Category:Neuropathology tumours]]
[[Category:WHO grade II tumours]]
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