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Difference between revisions of "Olfactory neuroblastoma"
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Olfactory neuroblastoma (view source)
Revision as of 06:53, 22 October 2019
, 06:53, 22 October 2019→IHC: S-100 in neuronal ONB
Jensflorian (talk | contribs) (→Molecular: corr) |
Jensflorian (talk | contribs) (→IHC: S-100 in neuronal ONB) |
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*[http://path.upmc.edu/cases/case467/images/fig02.jpg Olfactory neuroblastoma - crappy image (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case467.html http://path.upmc.edu/cases/case467.html]. Accessed on: 21 January 2012.</ref> | *[http://path.upmc.edu/cases/case467/images/fig02.jpg Olfactory neuroblastoma - crappy image (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case467.html http://path.upmc.edu/cases/case467.html]. Accessed on: 21 January 2012.</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811627/figure/Fig6/ Olfactory neuroblastoma (nih.gov)].<ref name=pmid20596981/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811627/figure/Fig6/ Olfactory neuroblastoma (nih.gov)].<ref name=pmid20596981/> | ||
<gallery> | |||
File:Esthesioneuroblastoma HE.jpg | Olfactory neuroblastoma (H&E). | |||
File:Olfactory neuroblastoma.jpg | Olfactory neuroblastoma (AFIP). | |||
File:Esthesioneuroblastoma.jpg | Sustenticular cells in ONB (AFIP). | |||
</gallery> | |||
==IHC== | ==IHC== | ||
*S-100: | *S-100: | ||
**Small round cells -ve. | |||
**Sustentacular cells +ve. | **Sustentacular cells +ve. | ||
** | ***Neuronal ONB subtype is enriched for the presence of S100 sustentacular cells. | ||
*[[Neuroendocrine markers]] +ve (CD56, synaptophysin). | *[[Neuroendocrine markers]] +ve (CD56, synaptophysin). | ||
**lower expression of neuroendocrine markers in IDH2 mutant tumors. | **lower expression of neuroendocrine markers in IDH2 mutant tumors. | ||
| Line 63: | Line 70: | ||
[[Category:Head and neck pathology]] | [[Category:Head and neck pathology]] | ||
[[Categorgy:Neuropathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||