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Olfactory neuroblastoma (view source)
Revision as of 06:53, 22 October 2019
, 06:53, 22 October 2019→IHC: S-100 in neuronal ONB
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*[http://path.upmc.edu/cases/case467/images/fig02.jpg Olfactory neuroblastoma - crappy image (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case467.html http://path.upmc.edu/cases/case467.html]. Accessed on: 21 January 2012.</ref> | *[http://path.upmc.edu/cases/case467/images/fig02.jpg Olfactory neuroblastoma - crappy image (upmc.edu)].<ref>URL: [http://path.upmc.edu/cases/case467.html http://path.upmc.edu/cases/case467.html]. Accessed on: 21 January 2012.</ref> | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811627/figure/Fig6/ Olfactory neuroblastoma (nih.gov)].<ref name=pmid20596981/> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811627/figure/Fig6/ Olfactory neuroblastoma (nih.gov)].<ref name=pmid20596981/> | ||
<gallery> | |||
File:Esthesioneuroblastoma HE.jpg | Olfactory neuroblastoma (H&E). | |||
File:Olfactory neuroblastoma.jpg | Olfactory neuroblastoma (AFIP). | |||
File:Esthesioneuroblastoma.jpg | Sustenticular cells in ONB (AFIP). | |||
</gallery> | |||
==IHC== | ==IHC== | ||
*S-100: | *S-100: | ||
**Small round cells -ve. | |||
**Sustentacular cells +ve. | **Sustentacular cells +ve. | ||
** | ***Neuronal ONB subtype is enriched for the presence of S100 sustentacular cells. | ||
*[[Neuroendocrine markers]] +ve (CD56, synaptophysin). | *[[Neuroendocrine markers]] +ve (CD56, synaptophysin). | ||
**lower expression of neuroendocrine markers in IDH2 mutant tumors. | **lower expression of neuroendocrine markers in IDH2 mutant tumors. | ||
| Line 51: | Line 58: | ||
==Molecular== | ==Molecular== | ||
* Two major subgroups.<ref>{{Cite journal | last1 = Capper | first1 = D. | last2 = Engel | first2 = NW. | last3 = Stichel | first3 = D. | last4 = Lechner | first4 = M. | last5 = Glöss | first5 = S. | last6 = Schmid | first6 = S. | last7 = Koelsche | first7 = C. | last8 = Schrimpf | first8 = D. | last9 = Niesen | first9 = J. | title = DNA methylation-based reclassification of olfactory neuroblastoma. | journal = Acta Neuropathol | volume = 136 | issue = 2 | pages = 255-271 | month = 08 | year = 2018 | doi = 10.1007/s00401-018-1854-7 | PMID = 29730775 }}</ref><ref>{{Cite journal | last1 = Classe | first1 = M. | last2 = Yao | first2 = H. | last3 = Mouawad | first3 = R. | last4 = Creighton | first4 = CJ. | last5 = Burgess | first5 = A. | last6 = Allanic | first6 = F. | last7 = Wassef | first7 = M. | last8 = Leroy | first8 = X. | last9 = Verillaud | first9 = B. | title = Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny. | journal = Cell Rep | volume = 25 | issue = 3 | pages = 811-821.e5 | month = 10 | year = 2018 | doi = 10.1016/j.celrep.2018.09.047 | PMID = 30332658 }}</ref> | * Two major subgroups.<ref>{{Cite journal | last1 = Capper | first1 = D. | last2 = Engel | first2 = NW. | last3 = Stichel | first3 = D. | last4 = Lechner | first4 = M. | last5 = Glöss | first5 = S. | last6 = Schmid | first6 = S. | last7 = Koelsche | first7 = C. | last8 = Schrimpf | first8 = D. | last9 = Niesen | first9 = J. | title = DNA methylation-based reclassification of olfactory neuroblastoma. | journal = Acta Neuropathol | volume = 136 | issue = 2 | pages = 255-271 | month = 08 | year = 2018 | doi = 10.1007/s00401-018-1854-7 | PMID = 29730775 }}</ref><ref>{{Cite journal | last1 = Classe | first1 = M. | last2 = Yao | first2 = H. | last3 = Mouawad | first3 = R. | last4 = Creighton | first4 = CJ. | last5 = Burgess | first5 = A. | last6 = Allanic | first6 = F. | last7 = Wassef | first7 = M. | last8 = Leroy | first8 = X. | last9 = Verillaud | first9 = B. | title = Integrated Multi-omic Analysis of Esthesioneuroblastomas Identifies Two Subgroups Linked to Cell Ontogeny. | journal = Cell Rep | volume = 25 | issue = 3 | pages = 811-821.e5 | month = 10 | year = 2018 | doi = 10.1016/j.celrep.2018.09.047 | PMID = 30332658 }}</ref> | ||
**Classical. | **Classical ("neural"). | ||
**G-CIMP +ve with frequent IDH2 R172 mutations. | **Basal: G-CIMP+ve with frequent IDH2 R172 mutations. | ||
==See also== | ==See also== | ||
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[[Category:Head and neck pathology]] | [[Category:Head and neck pathology]] | ||
[[Categorgy:Neuropathology]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||