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The general topic of ''head and neck pathology'' is covered in the ''[[head and neck pathology]]'' and ''[[head and neck cytopathology]]'' articles. | The general topic of ''head and neck pathology'' is covered in the ''[[head and neck pathology]]'' and ''[[head and neck cytopathology]]'' articles. | ||
The vast majority of oral malignancies are [[squamous cell carcinoma]]. Common odontogenic cysts are [[dentigerous cyst]]s, and [[radicular cyst]]s.<ref name=pmid20303056>{{Cite journal | last1 = Eichhorn | first1 = W. | last2 = Wehrmann | first2 = M. | last3 = Blessmann | first3 = M. | last4 = Pohlenz | first4 = P. | last5 = Blake | first5 = F. | last6 = Schmelzle | first6 = R. | last7 = Heiland | first7 = M. | title = Metastases in odontogenic cysts: literature review and case presentation. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod | volume = 109 | issue = 4 | pages = 582-6 | month = Apr | year = 2010 | doi = 10.1016/j.tripleo.2009.11.013 | PMID = 20303056 }}</ref> | |||
=Tooth histology 101= | =Tooth histology 101= | ||
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*Hyperchromatic (dark purple). | *Hyperchromatic (dark purple). | ||
*"Fish scale" appearance. | *"Fish scale" appearance. | ||
Image: | |||
<gallery> | |||
Image:Tooth_in_teratoma_-_very_low_mag.jpg | Tooth. (WC) | |||
</gallery> | |||
===Enamel 101=== | ===Enamel 101=== | ||
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Squamous epithelium - '' | *Squamous epithelium - non-keratinized - '''important'''. | ||
*+/-Giant cells. | *+/-Giant cells. | ||
*+/-Cholesterol clefts. | *+/-Cholesterol clefts. | ||
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*Unerupted tooth - usually wisdom teeth. | *Unerupted tooth - usually wisdom teeth. | ||
**Young adults. | **Young adults. | ||
Treatment: | |||
*Complete removal - as may transform to [[squamous cell carcinoma]] or [[ameloblastoma]].<ref>{{Ref PBoD8|748}}</ref> | |||
===Gross=== | ===Gross=== | ||
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Squamous epithelium - '' | *Squamous epithelium. | ||
**Classically described as non-keratinized - in which case the diagnosis is straight forward - '''important'''. | |||
**Approximately half have keratin.<ref name=pmid9195629>{{Cite journal | last1 = Yoshiura | first1 = K. | last2 = Higuchi | first2 = Y. | last3 = Araki | first3 = K. | last4 = Shinohara | first4 = M. | last5 = Kawazu | first5 = T. | last6 = Yuasa | first6 = K. | last7 = Tabata | first7 = O. | last8 = Kanda | first8 = S. | title = Morphologic analysis of odontogenic cysts with computed tomography. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod | volume = 83 | issue = 6 | pages = 712-8 | month = Jun | year = 1997 | doi = | PMID = 9195629 }}</ref> | |||
*+/-Giant cells. | *+/-Giant cells. | ||
*+/-Cholesterol clefts. | *+/-Cholesterol clefts. | ||
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DDx: | DDx: | ||
*[[Radicular cyst]] - history is the '''key''' to differentiate. | *[[Radicular cyst]] - history is the '''key''' to differentiate. | ||
*[[Keratocystic odontogenic tumour]] - | *[[Keratocystic odontogenic tumour]] - parakeratosis, ribbon like, (artefactual) clefting. | ||
Images: | Images: | ||
*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170149187 Dentigerous cyst (surgicalpathologyatlas.com)]. | *[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802170149187 Dentigerous cyst (surgicalpathologyatlas.com)]. | ||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180832/figure/F2/ Dentigerous cyst (nih.gov)].<ref name=pmid21957386>{{Cite journal | last1 = Moosvi | first1 = Z. | last2 = Tayaar | first2 = SA. | last3 = Kumar | first3 = GS. | title = Neoplastic potential of odontogenic cysts. | journal = Contemp Clin Dent | volume = 2 | issue = 2 | pages = 106-9 | month = Apr | year = 2011 | doi = 10.4103/0976-237X.83073 | PMID = 21957386 | PMC = 3180832 }}</ref> | *[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180832/figure/F2/ Dentigerous cyst (nih.gov)].<ref name=pmid21957386>{{Cite journal | last1 = Moosvi | first1 = Z. | last2 = Tayaar | first2 = SA. | last3 = Kumar | first3 = GS. | title = Neoplastic potential of odontogenic cysts. | journal = Contemp Clin Dent | volume = 2 | issue = 2 | pages = 106-9 | month = Apr | year = 2011 | doi = 10.4103/0976-237X.83073 | PMID = 21957386 | PMC = 3180832 }}</ref> | ||
===Sign out=== | |||
====Keratinized==== | |||
<pre> | |||
MAXILLARY SINUS CYST, LEFT, EXCISION: | |||
- ACANTHOTIC STRATIFIED SQUAMOUS EPITHELIUM WITH INFLAMMATION, COMPACT | |||
KERATIN AND FOCAL PARAKERATOSIS -- CONSISTENT WITH DENTIGEROUS CYST WITH KERATIN. | |||
- BENIGN BONE. | |||
- NEGATIVE FOR ODONTOGENIC KERATOCYSTIC TUMOUR (ODONTOGENIC KERATOCYST). | |||
</pre> | |||
==Keratocystic odontogenic tumour== | ==Keratocystic odontogenic tumour== | ||
{{Main|Keratocystic odontogenic tumour}} | |||
==Ameloblastoma== | ==Ameloblastoma== | ||
{{Main|Ameloblastoma}} | |||
==Adenomatoid odontogenic tumour== | ==Adenomatoid odontogenic tumour== | ||
{{Main|Adenomatoid odontogenic tumour}} | |||
==Ameloblastic fibroma== | ==Ameloblastic fibroma== | ||
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*Benign tumour of mesenchymal origin. | *Benign tumour of mesenchymal origin. | ||
*Often reoccurs. | *Often reoccurs. | ||
*Radiologic DDx includes ameloblastoma. | *Radiologic DDx includes [[ameloblastoma]]. | ||
===Gross=== | ===Gross=== | ||
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Features: | Features: | ||
*Paucicellular lesion with pale staining. | *Paucicellular lesion with pale staining. | ||
==Squamous odontogenic tumour== | |||
{{Main|Squamous odontogenic tumour}} | |||
=See also= | =See also= | ||
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[[Category:Head and neck pathology]] | [[Category:Head and neck pathology]] | ||
[[Category:Odontogenic tumours and cysts|Odontogenic tumours and cysts]] |
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