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Difference between revisions of "Nucleus-to-cytoplasm ratio"
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'''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated '''NC ratio'''. | '''Nucleus-to-cytoplasm ratio''', also '''nuclear-cytoplasmic ratio''', is the relative size of the nucleus to the cytoplasm. It is commonly abbreviated '''NC ratio'''. | ||
High NC ratio is strong predictor of [[malignancy]].<ref name=pmid16556320>{{Cite journal | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue = | pages = 11 | month = | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }} | High NC ratio is a strong predictor of [[malignancy]].<ref name=pmid16556320>{{Cite journal | last1 = Mehrotra | first1 = R. | last2 = Gupta | first2 = A. | last3 = Singh | first3 = M. | last4 = Ibrahim | first4 = R. | title = Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions. | journal = Mol Cancer | volume = 5 | issue = | pages = 11 | month = | year = 2006 | doi = 10.1186/1476-4598-5-11 | PMID = 16556320 | URL = http://www.biomedcentral.com/1476-4598/5/11 }} | ||
</ref> Like very rule, there are exceptions. | </ref> Like very rule, there are exceptions. | ||
NC ratio is a better predictor of malignancy than increased nuclear size. | |||
===High NC ratio in normal cells=== | ===High NC ratio in normal cells=== | ||
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The classic malignant high NC ratio cell is [[small cell carcinoma]], which is in the large ''[[small round cell tumour]]'' group. | The classic malignant high NC ratio cell is [[small cell carcinoma]], which is in the large ''[[small round cell tumour]]'' group. | ||
*Many other tumours - see ''[[A long differential diagnosis of small blue cell tumours]]''. | *Many other tumours - see ''[[A long differential diagnosis of small blue cell tumours]]''. | ||
*Preoperative treatment may increase NC ratio - example: pituitary adenoma under bromocriptine treatment.<ref>{{Cite journal | last1 = Nissim | first1 = M. | last2 = Ambrosi | first2 = B. | last3 = Bernasconi | first3 = V. | last4 = Giannattasio | first4 = G. | last5 = Giovanelli | first5 = MA. | last6 = Bassetti | first6 = M. | last7 = Vaccari | first7 = U. | last8 = Moriondo | first8 = P. | last9 = Spada | first9 = A. | title = Bromocriptine treatment of macroprolactinomas: studies on the time course of tumor shrinkage and morphology. | journal = J Endocrinol Invest | volume = 5 | issue = 6 | pages = 409-15 | month = | year = | doi = 10.1007/BF03350542 | PMID = 7169515 }}</ref> | |||
===Atypical cells with a normal NC ratio=== | ===Atypical cells with a normal NC ratio=== | ||