Nuclear pseudoinclusions

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Nuclear pseudoinclusions are cytoplasmic invaginations into the nucleus that mimic true nuclear inclusion.

A pseudoinclusion in papillary thyroid carcinoma.

Nuclear pseudoinclusions and true nuclear inclusions

True nuclear inclusions consist of material that is:

  1. Foreign to the nucleus.
  2. Completely contained within the nucleus.

They are classically caused by viral particles; however, there are other causes.[1]

Tumours with pseudoinclusions


  • The above is not an exhaustive list.

Pseudoinclusions in benign processes

See also


  1. Ip, YT.; Dias Filho, MA.; Chan, JK. (Dec 2010). "Nuclear inclusions and pseudoinclusions: friends or foes of the surgical pathologist?". Int J Surg Pathol 18 (6): 465-81. doi:10.1177/1066896910385342. PMID 21081532.
  2. URL: Accessed on: 28 April 2010.
  3. URL: Accessed on: 25 October 2010.
  4. Perry, Arie; Brat, Daniel J. (2010). Practical Surgical Neuropathology: A Diagnostic Approach: A Volume in the Pattern Recognition series (1st ed.). Churchill Livingstone. pp. 194. ISBN 978-0443069826.
  5. Arias-Stella, J. (Jan 2002). "The Arias-Stella reaction: facts and fancies four decades after.". Adv Anat Pathol 9 (1): 12-23. PMID 11756756.
  6. Dardi, LE.; Ariano, L.; Ariano, MC.; Gould, VE. (1982). "Arias-Stella reaction with prominent nuclear pseudoinclusions simulating herpetic endometritis.". Diagn Gynecol Obstet 4 (2): 127-32. PMID 6284466.