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Difference between revisions of "Non-malignant skin disease"
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Non-malignant skin disease (view source)
Revision as of 20:34, 29 January 2012
, 20:34, 29 January 2012→Granuloma annulare
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**Necrotic collagen - '''key feature'''. | **Necrotic collagen - '''key feature'''. | ||
***Nuclei "missing" - have undergone karyolysis. | ***Nuclei "missing" - have undergone karyolysis. | ||
**Mucin. | **Mucin - important. | ||
***Loose/pale, paucicellular, eosinophilic. | ***Loose/pale, paucicellular, eosinophilic. | ||
*Chronic inflammatory cells. | *Chronic inflammatory cells. | ||
| Line 408: | Line 408: | ||
DDx: | DDx: | ||
*[[Necrobiosis lipoidica]] - little mucin, no normal dermis between foci,<ref name=Ref_Derm51>{{Ref Derm|51}}</ref> plasma cells - common.<ref name=dermnetnz_nl>URL: [http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html]. Accessed on: 24 January 2012.</ref> | *[[Necrobiosis lipoidica]] - little mucin, no normal dermis between foci,<ref name=Ref_Derm51>{{Ref Derm|51}}</ref> plasma cells - common.<ref name=dermnetnz_nl>URL: [http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html http://dermnetnz.org/pathology/necrobiosis-lipoidica-path.html]. Accessed on: 24 January 2012.</ref> | ||
*[[Rheumatoid nodule]]. | *[[Rheumatoid nodule]] - has fibrin in the core of the granuloma (instead of mucin).<ref name=Ref_Derm52>{{Ref Derm|52}}</ref> | ||
Images: | Images: | ||
*[http://www.dermaamin.com/site/histopathology-of-the-skin/61-i/1813-interstitial-granuloma-annulare-.html Granuloma annulare (dermaamin.com)]. | *[http://www.dermaamin.com/site/histopathology-of-the-skin/61-i/1813-interstitial-granuloma-annulare-.html Granuloma annulare (dermaamin.com)]. | ||
===Stains=== | |||
*Alcian blue +ve (mucin).<ref name=Ref_Derm51>{{Ref Derm|51}}</ref> | |||
==Necrobiosis lipoidica== | ==Necrobiosis lipoidica== | ||