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Difference between revisions of "Non-malignant skin disease"
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Non-malignant skin disease (view source)
Revision as of 03:11, 11 September 2011
, 03:11, 11 September 2011→Pilomatricoma: tweak
m (→Systemic lupus erythematosus: mv dermatomyositis here) |
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===General=== | ===General=== | ||
*Benign skin tumour. | *Benign skin tumour. | ||
*Most common solid skin tumour of children.<ref name=emed1058965>[http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]</ref> | *Most common solid skin tumour of children.<ref name=emed1058965>URL: [http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]. Accessed on: 10 September 2011.</ref> | ||
*CTNNB1 gene mutation important in pathogenesis.<ref name=Ref_PCPBoD8_597>{{Ref PCPBoD8|597}}</ref> | |||
Clinical: | Clinical: | ||
*Hard nodule - calcification. | *Hard nodule - calcification. | ||
*+/-Painful. | *+/-Painful. | ||
Treatment: | Treatment: | ||
| Line 311: | Line 312: | ||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=emed1058965dx>[http://emedicine.medscape.com/article/1058965-diagnosis http://emedicine.medscape.com/article/1058965-diagnosis]</ref> | Features:<ref name=emed1058965dx>URL: [http://emedicine.medscape.com/article/1058965-diagnosis http://emedicine.medscape.com/article/1058965-diagnosis]. Accessed on: 10 September 2011.</ref> | ||
* | *Lower dermis/subcutaneous adipose lesion; thus, usu. surrounded by connective tissue. | ||
*Sharpy demarcated island of cells. | **Sharpy demarcated island of cells. | ||
*Calcification in 75% - with calcium staining (von Kossa). | **Calcification in 75% - with calcium staining (von Kossa). | ||
*Cells:<ref>[http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02d.htm http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02d.htm]</ref> | *Cells:<ref>[http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02d.htm http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02d.htm]</ref> | ||
**Basaloid epithelial cells - have prominent nucleoli. | **Basaloid epithelial cells - have prominent nucleoli. | ||
**Anucleate squamous cells ("ghost cells"). | **Anucleate squamous cells ("ghost cells"). | ||
*Giant cell foreign body type [[granulomas]] (form in reaction to keratin). | **Giant cell foreign body type [[granulomas]] (form in reaction to keratin). | ||
Notes: | Notes: | ||