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Difference between revisions of "Non-malignant skin disease"
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→Lichen planus: more
(→Lichen planus: more) |
(→Lichen planus: more) |
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Etiology: | Etiology: | ||
*Autoimmune disease, T-cell–mediated.<ref>URL: [http://emedicine.medscape.com/article/1078327-overview http://emedicine.medscape.com/article/1078327-overview]. Accessed on: 11 September 2010.</ref> | *Autoimmune disease, T-cell–mediated.<ref>URL: [http://emedicine.medscape.com/article/1078327-overview http://emedicine.medscape.com/article/1078327-overview]. Accessed on: 11 September 2010.</ref> | ||
Clinical:<ref name=Ref_PBoD8_1191>{{Ref PBoD8|1191}}</ref> | |||
*6 Ps: pruritic (itchy), purple, polygonal, planar papules and plaques. | |||
===Microscopy=== | ===Microscopy=== | ||
Features:<ref>URL: [http://emedicine.medscape.com/article/1078327-overview http://emedicine.medscape.com/article/1078327-overview]. Accessed on: 11 September 2010.</ref> | Features:<ref>URL: [http://emedicine.medscape.com/article/1078327-overview http://emedicine.medscape.com/article/1078327-overview]. Accessed on: 11 September 2010.</ref><ref name=Ref_PBoD8_1192>{{Ref PBoD8|1192}}</ref> | ||
*Loss of basal cells (stratum basale) -- '''key feature'''. | *Loss of basal cells (stratum basale) -- '''key feature'''. | ||
*Loss of rete ridges. | *Loss of rete ridges/formation of pointed rete ridges "sawtoothing". | ||
*Interface dermatitis (lymphocytes at dermal-epidermal junction). | *Interface dermatitis (lymphocytes at dermal-epidermal junction). | ||
*Hypergranulosis; stratum granulosum thickened (grossly seen as "Wickham stria" = white lines). | |||
*Hyperkeratosis; stratum corneum thickened. | |||
Notes: | |||
*Hyperkeratosis and hypergranulosis are not seen in [[erythema multiforme]]. | |||
Images: | Images: | ||