Difference between revisions of "Non-malignant skin disease"

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Non-malignant skin disease (view source)

Revision as of 15:47, 3 July 2013

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→‎Pilomatricoma: redirect
(→‎Dermatofibroma: split out)
(→‎Pilomatricoma: redirect)
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==Pilomatricoma==
==Pilomatricoma==
*[[AKA]] ''calcifying epithelioma of Malherbe''<ref>{{Ref Derm|387}}</ref>, [[AKA]] ''pilomatrixoma''.
{{Main|Pliomatricoma}}
===General===
*Benign skin tumour.
*Most common solid skin tumour of children.<ref name=emed1058965>URL: [http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]. Accessed on: 10 September 2011.</ref>
*CTNNB1 gene mutation important in pathogenesis.<ref name=Ref_PCPBoD8_597>{{Ref PCPBoD8|597}}</ref>
 
Clinical:
*Hard nodule - calcification.
*+/-Painful.
 
Treatment:
*Surgical excision.<ref name=emed1058965>[http://emedicine.medscape.com/article/1058965-overview http://emedicine.medscape.com/article/1058965-overview]</ref>
 
===Microscopic===
Features:<ref name=emed1058965dx>URL: [http://emedicine.medscape.com/article/1058965-diagnosis http://emedicine.medscape.com/article/1058965-diagnosis]. Accessed on: 10 September 2011.</ref>
*Nodular circumscribed lower dermis/subcutaneous adipose lesion; thus, usu. surrounded by connective tissue.
**Sharpy demarcated island of cells.
**Calcification in 75%.
*Cells:<ref>[http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02d.htm http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02d.htm]</ref>
**Basaloid epithelial cells - have prominent nucleoli.
**Anucleate squamous cells ("ghost cells").
**Giant cell foreign body type [[granulomas]] (form in reaction to keratin).
 
Notes:
*Keratin a prominent feature on cytology - lots of orange stuff.
*May ossify.
 
Images:
*[http://www.bccancer.bc.ca/HPI/CE/cytotechnology/cytosleuthquiz/nongyne/ngcase02.htm Pilomatrixoma - cytology (bccancer.bc.ca)].
*[http://www.dermrounds.com/photo/1980062:Photo:431 Pilomatrixoma - histology (dermrounds.com)].
*[http://en.wikipedia.org/wiki/File:Pilomatrixoma_-_high_mag.jpg Pilomatrixoma - high mag. (WC)].
*[http://en.wikipedia.org/wiki/File:Pilomatrixoma_-_intermed_mag.jpg Pilomatrixoma - intermed. mag. (WC)].
 
DDx:
*[[Epidermal inclusion cyst]].
*Pilomatrix carcinoma - invasive border, cytologic atypia, necrosis.<ref>{{Ref Derm|389}}</ref>
*[[Squamous cell carcinoma]].
*[[Basal cell carcinoma]].
 
===Sign out===
<pre>
SKIN LESION, RIGHT ARM, EXCISION:
- PILOMATRICOMA.
</pre>


==Dermatofibroma==
==Dermatofibroma==
Michael
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